Aid by Sector
Improving access to asthma care for children and adolescents in Uganda
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC ARL award to understand whether innovations like checking every child and adolescent visiting primary care health facilities for asthma symptoms can lead to an increase in the number of children diagnosed with asthma, and whether education about asthma directed to patients and their caregivers can lead to improvements in the understanding of asthma, use of medicines and subsequent reduction in frequency of symptoms.
Unravelling the mechanisms of neurological damage during cryptococcal infection of the brain
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC ARL award, Cryptococcal meningitis kills more than 200,000 people each year in Sub-Saharan Africa and also causes neurological dysfunction and disability in survivors, most of which are of an economically productive age. Cryptococcal meningitis (CM) is the leading cause of HIV-associated meningitis, which is characterised by debilitating, inflammatory injury of the brain and a very high chance of death, even with treatment. In Sub-Saharan Africa, the number of people who die from CM and its complications is worsened by the unavailability and inaccessibility of safe and effective drugs. This research will fill the existing knowledge gap on how the brain is injured in cryptococcal meningitis. This models and methods would then serve as a platform for studying the mechanisms of other infections of the Central Nervous System that are caused by bacteria, parasites and viruses to inform the development of the much-needed new therapies in South Africa and the wider Sub-Saharan Africa region.
Responding to the needs of Women and Children in Yemen 301140
UK - Foreign, Commonwealth Development Office (FCDO)
This programme will address the devastating impact the conflict in Yemen is having on women and children, particularly the most marginalised. It will provide access to life-saving integrated health, nutrition, water, sanitation and hygiene (WASH) and protection services. This approach responds directly to two key UK humanitarian aims in Yemen: preventing famine and ensuring respect for International Humanitarian Law.
The Evidence Fund - 300708
UK - Foreign, Commonwealth Development Office (FCDO)
The Evidence Fund procures and manages research and evaluations that primarily benefit ODA eligible countries. Most research and evaluations paid for by the Evidence Fund are country-specific, and all respond to requests for evidence to inform programme or policy decisions. Primarily serving research requests from HMG’s Embassies and High Commissions in ODA eligible countries, and from HMG policy and strategy teams, the Evidence Fund strengthens the evidence behind the UK’s priority international development investments and development diplomacy. The Evidence Fund also invests modest amounts of non-ODA, to strengthen the evidence behind wider UK foreign policy.
I2I - Ideas to Impact - Testing new technologies and innovative approaches to address development challenges.
UK - Foreign, Commonwealth Development Office (FCDO)
I2I stimulates technological innovations addressing intractable development challenges, initially in the focal areas of energy, water and climate, and then increasingly in emerging “frontier” technologies with broader applicability. It tests different funding mechanisms and approaches - including prizes, peer-to-peer financing, Frontier Technology Livestreaming, and innovative cross-government partnerships - for ensuring technology ideas lead to a real-world development impact.
Investing in Human Capital through Partnerships Beyond Aid in the Social Sectors Programme
UK - Foreign, Commonwealth Development Office (FCDO)
To improve governance and accountability in education, health and social protection sectors and contribute to policy and research which will inform interventions to improve equity and reduce poverty.
Health Resilience Fund in Zimbabwe 2021-2025
UK - Foreign, Commonwealth Development Office (FCDO)
To support a resilient health system in Zimbabwe that is equipped to deliver quality sexual, reproductive, maternal, newborn, child and adolescent health and nutrition services.
LAFIYA -UK Support for Health in Nigeria
UK - Foreign, Commonwealth Development Office (FCDO)
To save lives, reduce suffering and improve economic prospects for the poorest and most vulnerable in Nigeria through: i. Encouraging Government of Nigeria to increase resources invested in health (through advocacy, community accountability; and data to inform government prioritisation using a “delivery” approach, as used successfully in Pakistan) ii. Improving effectiveness and efficiency of public and private basic health services (through innovative financing mechanisms, strengthening health systems and working with private sector to deliver affordable health services for the poorest populations) iii. Reducing total fertility rate (through addressing social norms, demographic impact analysis, and support to family planning commodities and services).
South Sudan Health Pooled Fund Phase III
UK - Foreign, Commonwealth Development Office (FCDO)
To provide a government led effective health system that will deliver improved access to quality health services across seven states in South Sudan with a specific focus on reducing maternal and child mortality. The Health Pooled Fund (HPF3) will reduce maternal and under-five mortality rates in South Sudan, through (i) the delivery of a basic package of health and nutrition services; (ii) promoting community engagement in health as a public good and (iii) supporting local health systems stabilisation.
Tanzania Health Resilience Programme
UK - Foreign, Commonwealth Development Office (FCDO)
Drawing on the UK’s comparative advantage and priorities, and in line with Tanzania’s health sector strategy, the programme will: 1. Increase access, quality and equity of life-saving primary health care services by strengthening health systems that support ending preventable deaths of mothers, new-borns, and children (EPD). 2. Strengthen government ability to respond to health threats by supporting integrated disease surveillance systems at community level, and support preparedness systems and the initial response to disease outbreaks. 3. Support the increase and use of data to inform decision making and resource allocation to deliver equitable health outcomes. The programme will support Tanzania to regain momentum towards achieving Universal Health Coverage (UHC) by 2030 as measured by a change in Tanzania’s UHC index.
UK Public Health Rapid Support Team (UK-PHRST) - Research
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC). The UK Public Health Rapid Support Team (UK-PHRST) is the primary mechanism for the UK Government to deploy technical expertise in outbreak response to ODA-eligible countries, stopping a public health threat from becoming a broader health emergency. It is a partnership between the UK Health Security Agency (UKHSA, formerly Public Health England (PHE)) and the London School of Hygiene and Tropical Medicine (LSHTM) and was established in 2016 in response to lessons learned from the West Africa Ebola outbreak. The UK-PHRST comprises public health experts who work to address the threat posed by infectious disease outbreaks in low- and middle- income countries (LMICs) through an integrated triple remit of: (1) Outbreak Response: Rapidly investigate and respond to disease outbreaks at source in LMICs to stop a public health threat from becoming a broader health emergency by deploying specialist public health experts; (2) Research: Deliver rigorous, collaborative research with partners to improve the evidence base for best practice in epidemic preparedness and response; and (3) Capacity Strengthening: Strengthen leadership, systems and technical capacity for an improved response to disease outbreaks in ODA-eligible countries.
UK Vaccine Network (UKVN)
UK - Department of Health and Social Care (DHSC)
The UK Vaccine Network (UKVN) is an Official Development Assistance (ODA) funded UKaid programme from the UK Department of Health and Social Care (DHSC). It supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. The long-term aims of this programme are to prevent outbreaks of diseases with epidemic potential through proactive vaccination campaigns or to control them through quick development of new vaccines and/or responsive vaccination campaigns upon outbreak detection. UKVN focuses on human and zoonotic diseases with epidemic potential in humans, from 12 priority pathogen families, alongside Disease X (a pandemic pathogen that has not yet been characterised).
UK Vaccine Network (UKVN) - BactiVac Network - Bacterial Vaccinology Competition
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. The BactiVac Network aims to accelerate the development of vaccines against bacterial infections to reduce antimicrobial use in humans and animals, specifically in LMICs. UKVN funding to BactiVac supports projects that develop vaccines to prevent and/or minimise the emergence and transmission of antimicrobial resistance. A partnership between at least two organisations is a funding requirement, with at least one partner based in the UK, and prioritising partnerships with LMIC researchers. The primary aim of the funding is to encourage the establishment of new, diverse research projects and partnerships which can progress to gain preliminary data and establish their reputation, enabling them to obtain further investment. Funding will also support other UKVN activities which promote collaboration across the membership, particularly for members based in LMICs.
UK Vaccine Network (UKVN) - Coalition for Epidemic Preparedness Innovations (CEPI) - Development of Vaccines Against Diseases with Epidemic Potential
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. CEPI (the Coalition for Epidemic Preparedness Innovations) is a global public-private partnership established following the 2014-16 West African Ebola epidemic to accelerate development of, and equitable access to, vaccines against emerging infectious diseases of epidemic and pandemic potential. It pools funding from sovereign donors and major philanthropic organisations to: (1) Support the advancement of vaccine candidates for known priority pathogens in LMICs; (2) Advance vaccine platform technology to support accelerated responses to an unknown pathogen (Disease X); and (3) Address key barriers to vaccine access in LMICs, such as distribution of manufacturing capacity.
UK Vaccine Network (UKVN) - Engineering and Physical Sciences Research Council (EPSRC) - Future Vaccine Manufacturing Research Hubs Competition 2 (2023-2028)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN is collaborating with the Engineering and Physical Sciences Research Council (EPSRC) to run Stage 2 of the Vaccine Manufacturing Research Hubs competition, which funds four hubs (including the two funded in Stage 1). The first stage of the Future Vaccine Manufacturing Research Hubs competition prioritised the development of vaccine products through research into improved vaccine manufacturing. The second stage continues to fund work of the same nature. As in the first competition, the hubs seek to: (1) Develop tools and technologies that allow for easier and quicker manufacturing of vaccines in emergencies; (2) Redesign existing vaccines to make them cheaper and easier to manufacture and easier to deliver in LMIC settings; and (3) Provide bespoke support for researchers developing vaccines for diseases which primarily affect LMICs, so that the vaccines they are developing are as rapid and cost-effective to manufacture as possible. The projects are expected to collaborate with LMIC researchers and industry to support their work. This project was not put out to an open, competitive tender process because, as a non-departmental public body of the UK government, EPSRC is uniquely positioned to manage research calls.
UK Vaccine Network (UKVN) - Medicines and Healthcare products Regulatory Agency (MHRA) - Global Health Security
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. This project is a collaboration between UKVN, DHSC’s Global AMR Innovation Fund (GAMRIF) and the Medicines and Healthcare products Regulatory Agency (MHRA). The UKVN Work Package supports epidemic and pandemic preparedness by expanding the portfolio of research reagents for emerging viruses. Reagents are chemical compounds that trigger chemical reactions and are therefore vital to laboratory research and vaccine development. Simple and timely access to high quality research reagents would accelerate the development of vaccines against emerging infectious diseases, particularly for scientists from LMICs, which are frequently the worst affected. The existing Centre for AIDS Reagents (CFAR) repository at the MHRA has successfully provided a sustained research reagent resource to the scientific community since 1989. Using their existing network and successful operating model, UKVN funding allows CFAR to expand its scope to become the Centre for Infectious Disease Reagents (CIDR) and encourage leading laboratories to deposit state of the art research materials to their repository and produce and commission new reagents. These materials will be prioritised to organisations in LMICs which will benefit from free of charge access. For more information on the GAMRIF work package please see GB-GOV-10-GAMRIF-WP12-MHRA. This project was not put out to an open, competitive tender process because MHRA is an executive agency of DHSC and therefore exempt from the tender process as it is within DHSC’s body of expertise.
UK Vaccine Network (UKVN) - UK Health Security Agency (UKHSA) - Vaccine Technology Development
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN funded the UK Health Security Agency (UKHSA) to deliver a programme of seven projects that will advance vaccine development for diseases of epidemic potential for the benefit of people in LMICs. The projects cover a range of pathogens, which have been identified as being a priority area of investment due to lack of current vaccine availability and likelihood of epidemic threat. The projects are primarily focused on enabling activities, such as preclinical model or assay development, to support the development of vaccine candidates for priority pathogens, including through increasing the range of settings where vaccine development and evaluation can take place without a need for higher-containment facilities, which will support future work in LMICs. This project was not put out to an open, competitive tender process because UKHSA is an executive agency of DHSC with a mandate to deliver on pandemic preparedness and therefore exempt from the tender process as it is within DHSC’s body of expertise.
UK Vaccine Network (UKVN) - Innovate UK - Vaccine Development for Diseases with Epidemic Potential Competition
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN is funding Innovate UK to run the Vaccine Development for Diseases with Epidemic Potential competition. The competition aims to support projects seeking to develop vaccines, vaccine platform technologies and manufacturing technologies that will enable an effective, rapid response during future outbreaks of diseases of epidemic potential in LMICs. The projects include work that has progressed from earlier UKVN-Innovate UK competitions, including the Vaccines for Epidemic Diseases: Readiness for Clinical Development and Regulatory Submission Competition, Innovate Vaccine Development Competition 2017-2020, Innovate Preclinical Vaccine Development Competition 2017-2021, and Innovate Clinical Vaccine Development Competition 2018-2021. The successive funding allows for successful previous projects to receive follow on funding and progress vaccine candidates down the developmental pipeline. This project was not put out to an open, competitive tender process because, as a non-departmental public body of the UK government, Innovate UK is uniquely positioned to manage research calls.
UK Vaccine Network (UKVN) - Innovate UK - Vaccines for Epidemic Diseases: Readiness for clinical development and regulatory submission competition
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN collaborated with Innovate UK to run a Small Business Research Initiative (SBRI) competition to invest in vaccines and vaccine technologies to address the priority disease families identified by UKVN (including Disease X - a pandemic pathogen that has not yet been characterised). Proposals could address any part of the pre-clinical, non-clinical, manufacturing, or clinical pathway, within a one-year time frame, making technology ready to be progressed further along the developmental pathway. The projects built on work from previous Innovate competitions, including: Innovate Clinical Vaccine Development Competition 2018/2021, Innovate Pre-clinical Vaccine Development Competition 2017/2021 and the Innovate Vaccine Development Competition to develop research across vaccine development. This project was not put out to an open, competitive tender process because, as a non-departmental public body of the UK government, Innovate UK is uniquely positioned to manage research calls.
NIHR Global Health Research Units: Call 2
UK - Department of Health and Social Care (DHSC)
The NIHR's second Global Health Research call for Units. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMIC), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. Global Health Research Units are defined as a well-established research partnership or network of universities and research institutes in LMICs and the UK: 1. With an existing track-record of delivering internationally recognised applied global health research addressing unmet health needs in ODA-eligible countries; 2. Who wish to consolidate and expand this work, supporting and developing thematic research and capacity strengthening networks, through regional and global hubs; 3. Who will deliver a large scale, ambitious programme of applied health research through a range of trials and studies; 4. Who are able to leverage the strength of the existing partnership consortium to improve practice and inform policy based on scientific evidence; 5. Who will set up and deliver a substantial and sustainable programme of capacity and capability strengthening at individual and institutional level.
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