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DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY

Unravelling the mechanisms of neurological damage during cryptococcal infection of the brain

IATI Identifier: GB-GOV-13-OODA-MRC-C7R3CT3-7ELVWN4-824RABM
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Description

MRC ARL award, This research will fill the existing knowledge gap on how the brain is injured in cryptococcal meningitis. This models and methods would then serve as a platform for studying the mechanisms of other infections of the Central Nervous System that are caused by bacteria, parasites and viruses to inform the development of the much-needed new therapies.

Objectives

AIM 1: Determine the neuroimmune response of microglia and neurons to C. neoformans Objective 1.1: Characterise neuroimmune signalling pathways in microglial cells during C. neoformans infection Objective 1.2: Characterise the mechanisms and effects of neuronal invasion by C. neoformans Objective 1.3: Characterise cell-type specific gene expression during C. neoformans infection in organotypic slices using single-nucleus RNA sequencing AIM 2: Investigate the effect of cryptococcal entry and accumulation in brain compartments on fluid flow and neuroimmune homeostasis Objective 2.1: A spatiotemporal anatomopathological characterisation of cryptococcal infection of the mouse and human brain Objective 2.2: An investigation of the effect of cryptococcal infection on fluid transport in a mouse model of CM Objective 2.3: Characterise spatial gene expression profiles during C. neoformans infection in an in vivo rodent model of CM using spatial transcriptomic sequencing

Location

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South Africa
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Status Implementation

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Download IATI Data for GB-GOV-13-OODA-MRC-C7R3CT3-7ELVWN4-824RABM

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