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UK Public Health Rapid Support Team (UK-PHRST) - Research

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC). The UK Public Health Rapid Support Team (UK-PHRST) is the primary mechanism for the UK Government to deploy technical expertise in outbreak response to ODA-eligible countries, stopping a public health threat from becoming a broader health emergency. It is a partnership between the UK Health Security Agency (UKHSA, formerly Public Health England (PHE)) and the London School of Hygiene and Tropical Medicine (LSHTM) and was established in 2016 in response to lessons learned from the West Africa Ebola outbreak. The UK-PHRST comprises public health experts who work to address the threat posed by infectious disease outbreaks in low- and middle- income countries (LMICs) through an integrated triple remit of: (1) Outbreak Response: Rapidly investigate and respond to disease outbreaks at source in LMICs to stop a public health threat from becoming a broader health emergency by deploying specialist public health experts; (2) Research: Deliver rigorous, collaborative research with partners to improve the evidence base for best practice in epidemic preparedness and response; and (3) Capacity Strengthening: Strengthen leadership, systems and technical capacity for an improved response to disease outbreaks in ODA-eligible countries.

Programme Id GB-GOV-10-UKPHRST-LSHTM
Start date 2016-7-1
Status Implementation
Total budget £16,655,655

UK Vaccine Network (UKVN)

UK - Department of Health and Social Care (DHSC)

The UK Vaccine Network (UKVN) is an Official Development Assistance (ODA) funded UKaid programme from the UK Department of Health and Social Care (DHSC). It supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. The long-term aims of this programme are to prevent outbreaks of diseases with epidemic potential through proactive vaccination campaigns or to control them through quick development of new vaccines and/or responsive vaccination campaigns upon outbreak detection. UKVN focuses on human and zoonotic diseases with epidemic potential in humans, from 12 priority pathogen families, alongside Disease X (a pandemic pathogen that has not yet been characterised).

Programme Id GB-GOV-10-UKVN
Start date 2016-2-1
Status Implementation
Total budget £527,939,639.32

UK Vaccine Network (UKVN) - BactiVac Network - Bacterial Vaccinology Competition

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. The BactiVac Network aims to accelerate the development of vaccines against bacterial infections to reduce antimicrobial use in humans and animals, specifically in LMICs. UKVN funding to BactiVac supports projects that develop vaccines to prevent and/or minimise the emergence and transmission of antimicrobial resistance. A partnership between at least two organisations is a funding requirement, with at least one partner based in the UK, and prioritising partnerships with LMIC researchers. The primary aim of the funding is to encourage the establishment of new, diverse research projects and partnerships which can progress to gain preliminary data and establish their reputation, enabling them to obtain further investment. Funding will also support other UKVN activities which promote collaboration across the membership, particularly for members based in LMICs.

Programme Id GB-GOV-10-UKVN-BACTIVAC
Start date 2024-4-1
Status Implementation
Total budget £700,000

UK Vaccine Network (UKVN) - Coalition for Epidemic Preparedness Innovations (CEPI) - Development of Vaccines Against Diseases with Epidemic Potential

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. CEPI (the Coalition for Epidemic Preparedness Innovations) is a global public-private partnership established following the 2014-16 West African Ebola epidemic to accelerate development of, and equitable access to, vaccines against emerging infectious diseases of epidemic and pandemic potential. It pools funding from sovereign donors and major philanthropic organisations to: (1) Support the advancement of vaccine candidates for known priority pathogens in LMICs; (2) Advance vaccine platform technology to support accelerated responses to an unknown pathogen (Disease X); and (3) Address key barriers to vaccine access in LMICs, such as distribution of manufacturing capacity.

Programme Id GB-GOV-10-UKVN-CEPI
Start date 2018-12-14
Status Implementation
Total budget £70,000,000

UK Vaccine Network (UKVN) - Engineering and Physical Sciences Research Council (EPSRC) - Future Vaccine Manufacturing Research Hubs Competition 2 (2023-2028)

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN is collaborating with the Engineering and Physical Sciences Research Council (EPSRC) to run Stage 2 of the Vaccine Manufacturing Research Hubs competition, which funds four hubs (including the two funded in Stage 1). The first stage of the Future Vaccine Manufacturing Research Hubs competition prioritised the development of vaccine products through research into improved vaccine manufacturing. The second stage continues to fund work of the same nature. As in the first competition, the hubs seek to: (1) Develop tools and technologies that allow for easier and quicker manufacturing of vaccines in emergencies; (2) Redesign existing vaccines to make them cheaper and easier to manufacture and easier to deliver in LMIC settings; and (3) Provide bespoke support for researchers developing vaccines for diseases which primarily affect LMICs, so that the vaccines they are developing are as rapid and cost-effective to manufacture as possible. The projects are expected to collaborate with LMIC researchers and industry to support their work. This project was not put out to an open, competitive tender process because, as a non-departmental public body of the UK government, EPSRC is uniquely positioned to manage research calls.

Programme Id GB-GOV-10-UKVN-FVMRH-EPSRC-2.0
Start date 2023-9-1
Status Implementation
Total budget £33,047,900.47

UK Vaccine Network (UKVN) - Medicines and Healthcare products Regulatory Agency (MHRA) - Global Health Security

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. This project is a collaboration between UKVN, DHSC’s Global AMR Innovation Fund (GAMRIF) and the Medicines and Healthcare products Regulatory Agency (MHRA). The UKVN Work Package supports epidemic and pandemic preparedness by expanding the portfolio of research reagents for emerging viruses. Reagents are chemical compounds that trigger chemical reactions and are therefore vital to laboratory research and vaccine development. Simple and timely access to high quality research reagents would accelerate the development of vaccines against emerging infectious diseases, particularly for scientists from LMICs, which are frequently the worst affected. The existing Centre for AIDS Reagents (CFAR) repository at the MHRA has successfully provided a sustained research reagent resource to the scientific community since 1989. Using their existing network and successful operating model, UKVN funding allows CFAR to expand its scope to become the Centre for Infectious Disease Reagents (CIDR) and encourage leading laboratories to deposit state of the art research materials to their repository and produce and commission new reagents. These materials will be prioritised to organisations in LMICs which will benefit from free of charge access. For more information on the GAMRIF work package please see GB-GOV-10-GAMRIF-WP12-MHRA. This project was not put out to an open, competitive tender process because MHRA is an executive agency of DHSC and therefore exempt from the tender process as it is within DHSC’s body of expertise.

Programme Id GB-GOV-10-UKVN-MHRA
Start date 2024-4-5
Status Implementation
Total budget £1,002,469

UK Vaccine Network (UKVN) - UK Health Security Agency (UKHSA) - Vaccine Technology Development

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN funded the UK Health Security Agency (UKHSA) to deliver a programme of seven projects that will advance vaccine development for diseases of epidemic potential for the benefit of people in LMICs. The projects cover a range of pathogens, which have been identified as being a priority area of investment due to lack of current vaccine availability and likelihood of epidemic threat. The projects are primarily focused on enabling activities, such as preclinical model or assay development, to support the development of vaccine candidates for priority pathogens, including through increasing the range of settings where vaccine development and evaluation can take place without a need for higher-containment facilities, which will support future work in LMICs. This project was not put out to an open, competitive tender process because UKHSA is an executive agency of DHSC with a mandate to deliver on pandemic preparedness and therefore exempt from the tender process as it is within DHSC’s body of expertise.

Programme Id GB-GOV-10-UKVN-UKHSA
Start date 2024-5-30
Status Implementation
Total budget £3,087,868

UK Vaccine Network (UKVN) - Innovate UK - Vaccine Development for Diseases with Epidemic Potential Competition

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN is funding Innovate UK to run the Vaccine Development for Diseases with Epidemic Potential competition. The competition aims to support projects seeking to develop vaccines, vaccine platform technologies and manufacturing technologies that will enable an effective, rapid response during future outbreaks of diseases of epidemic potential in LMICs. The projects include work that has progressed from earlier UKVN-Innovate UK competitions, including the Vaccines for Epidemic Diseases: Readiness for Clinical Development and Regulatory Submission Competition, Innovate Vaccine Development Competition 2017-2020, Innovate Preclinical Vaccine Development Competition 2017-2021, and Innovate Clinical Vaccine Development Competition 2018-2021. The successive funding allows for successful previous projects to receive follow on funding and progress vaccine candidates down the developmental pipeline. This project was not put out to an open, competitive tender process because, as a non-departmental public body of the UK government, Innovate UK is uniquely positioned to manage research calls.

Programme Id GB-GOV-10-UKVN-VD2.0-IUK
Start date 2023-7-12
Status Implementation
Total budget £37,011,471

UK Vaccine Network (UKVN) - Innovate UK - Vaccines for Epidemic Diseases: Readiness for clinical development and regulatory submission competition

UK - Department of Health and Social Care (DHSC)

This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s UK Vaccine Network (UKVN) which supports the development of vaccines and vaccine technology for infectious diseases with the potential to cause an epidemic in low- and middle-income countries (LMICs), focusing on areas of market failure. UKVN has identified a range of human diseases with epidemic potential in LMICs for which the development of vaccines is a priority. UKVN collaborated with Innovate UK to run a Small Business Research Initiative (SBRI) competition to invest in vaccines and vaccine technologies to address the priority disease families identified by UKVN (including Disease X - a pandemic pathogen that has not yet been characterised). Proposals could address any part of the pre-clinical, non-clinical, manufacturing, or clinical pathway, within a one-year time frame, making technology ready to be progressed further along the developmental pathway. The projects built on work from previous Innovate competitions, including: Innovate Clinical Vaccine Development Competition 2018/2021, Innovate Pre-clinical Vaccine Development Competition 2017/2021 and the Innovate Vaccine Development Competition to develop research across vaccine development. This project was not put out to an open, competitive tender process because, as a non-departmental public body of the UK government, Innovate UK is uniquely positioned to manage research calls.

Programme Id GB-GOV-10-UKVN-VED-IUK
Start date 2023-3-31
Status Implementation
Total budget £10,117,286.66

National Institute for Health and Care Research (NIHR)’s second Global Research Professorship call

UK - Department of Health and Social Care (DHSC)

National Institute for Health and Care Research (NIHR)’s second Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC.

Programme Id GB-GOV-10-RP_02
Start date 2019-12-1
Status Implementation
Total budget £1,772,535

National Institute for Health and Care Research (NIHR)’s third Global Research Professorship call

UK - Department of Health and Social Care (DHSC)

National Institute for Health and Care Research (NIHR)’s third Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC.

Programme Id GB-GOV-10-RP_03
Start date 2021-2-1
Status Implementation
Total budget £3,832,448

National Institute for Health and Care Research (NIHR)’s fourth Global Research Professorship call

UK - Department of Health and Social Care (DHSC)

National Institute for Health and Care Research (NIHR)’s fourth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC.

Programme Id GB-GOV-10-RP_04
Start date 2021-12-1
Status Implementation
Total budget £5,847,173

National Institute for Health and Care Research (NIHR)’s fifth Global Research Professorship call

UK - Department of Health and Social Care (DHSC)

National Institute for Health and Care Research (NIHR)’s fifth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC.

Programme Id GB-GOV-10-RP_05
Start date 2023-1-1
Status Implementation
Total budget £7,788,969

National Institute for Health and Care Research (NIHR)’s sixth Global Research Professorship call

UK - Department of Health and Social Care (DHSC)

National Institute for Health and Care Research (NIHR)’s sixth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC.

Programme Id GB-GOV-10-RP_06
Start date 2024-1-1
Status Implementation
Total budget £13,777,964

National Institute for Health and Care Research (NIHR)’s seventh Global Research Professorship call

UK - Department of Health and Social Care (DHSC)

National Institute for Health and Care Research (NIHR)’s seventh Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC.

Programme Id GB-GOV-10-RP_07
Start date 2024-11-1
Status Implementation
Total budget £11,407,560

Applied Research for Adolescent Health in Low and Middle Income Countries

UK - Department of Health and Social Care (DHSC)

The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This initiative funds research grants to improve adolescent health in low- and middle-income countries (LMICs).

Programme Id GB-GOV-10-Adol_Health
Start date 2018-6-12
Status Implementation
Total budget £12,003,780

WHO Alliance for Health Policy and Systems Research Partnership

UK - Department of Health and Social Care (DHSC)

The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR works in partnership with the Alliance for Health Policy and Systems Research (AHPSR), a hosted partnership of the World Health Organization (WHO), to fund the generation and use of health policy and systems research as a means to strengthen the health systems of Low and Middle-Income Countries (LMICs).

Programme Id GB-GOV-10-AHPSR
Start date 2022-12-12
Status Implementation
Total budget £7,966,542

European and Developing Countries Clinical Trials Partnership (EDCTP) phase II

UK - Department of Health and Social Care (DHSC)

The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related diseases as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. The NIHR has supported research calls as part of the 2016, 2017 and 2018 workplans, in addition to programme management activities associated with enhancing the wider programme.

Programme Id GB-GOV-10-EDCTP2
Start date 2017-11-7
Status Implementation
Total budget £93,433,100

European and Developing Countries Clinical Trials Partnership (EDCTP) phase III

UK - Department of Health and Social Care (DHSC)

The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provides funding to the Global Health European and Developing Countries Clinical Trials Partnership 3 (Global Health EDCTP3) Joint Undertaking which works to deliver new solutions to reduce the burden of poverty-related infectious diseases in sub-Saharan Africa and to strengthen research capacities to prepare and respond to re-emerging infectious diseases. Global Health EDCTP3 builds on EDCTP Phase 2, which NIHR has been contributing to since 2016 (GB-GOV-10-EDCTP2). As EDCTP transitions to Global Health EDCTP3, calls under the new work packages will support further clinical research and training in sub-Saharan Africa.

Programme Id GB-GOV-10-EDCTP3
Start date 2023-12-8
Status Implementation
Total budget £30,088,385.78

Global Alliance for Chronic Diseases

UK - Department of Health and Social Care (DHSC)

The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The Global Alliance for Chronic Diseases (GACD) coordinates and supports research activities that address the prevention and treatment of chronic non-communicable diseases, on a global scale. The GACD is the first collaboration of major research funding agencies to specifically address chronic non-communicable diseases.

Programme Id GB-GOV-10-GACD
Start date 2018-6-12
Status Implementation
Total budget £11,333,843

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