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Unravelling the mechanisms of neurological damage during cryptococcal infection of the brain
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC ARL award, Cryptococcal meningitis kills more than 200,000 people each year in Sub-Saharan Africa and also causes neurological dysfunction and disability in survivors, most of which are of an economically productive age. Cryptococcal meningitis (CM) is the leading cause of HIV-associated meningitis, which is characterised by debilitating, inflammatory injury of the brain and a very high chance of death, even with treatment. In Sub-Saharan Africa, the number of people who die from CM and its complications is worsened by the unavailability and inaccessibility of safe and effective drugs. This research will fill the existing knowledge gap on how the brain is injured in cryptococcal meningitis. This models and methods would then serve as a platform for studying the mechanisms of other infections of the Central Nervous System that are caused by bacteria, parasites and viruses to inform the development of the much-needed new therapies in South Africa and the wider Sub-Saharan Africa region.
Improving access to asthma care for children and adolescents in Uganda
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC ARL award to understand whether innovations like checking every child and adolescent visiting primary care health facilities for asthma symptoms can lead to an increase in the number of children diagnosed with asthma, and whether education about asthma directed to patients and their caregivers can lead to improvements in the understanding of asthma, use of medicines and subsequent reduction in frequency of symptoms.
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