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WHO as a facilitator for equitable clinical trial capacity in low resourced settings
UK - Department of Health and Social Care (DHSC)
The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). DHSC is supporting the World Health Organization (WHO) between 2024-2026 to implement the World Health Assembly Clinical Trials Resolution with a focus on low and middle-income country (LMIC) settings. Intended impact is to deliver good practice guidelines to implement the WHA Resolution and improve capability and quality of clinical trials in particular in LMIC settings, including increasing participation by under-represented groups and improving ethical considerations.
WHO as a facilitator for equitable clinical trial capacity in low resourced settings
UK - Department of Health and Social Care (DHSC)
The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). DHSC is supporting the World Health Organization (WHO) between 2024-2026 to implement the World Health Assembly Clinical Trials Resolution with a focus on low and middle-income country (LMIC) settings. Intended impact is to deliver good practice guidelines to implement the WHA Resolution and improve capability and quality of clinical trials in particular in LMIC settings, including increasing participation by under-represented groups and improving ethical considerations.
Fleming Fund - Multilateral Grant to World Organisation for Animal Health (WOAH)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC). The Fleming Fund contributes to the World Organisation for Animal Health (WOAH) to support the implementation of its Strategy on Antimicrobial Resistance (AMR) and the prudent use of Antimicrobials. The strategy aligns with the Global Action Plan on Antimicrobial Resistance (GAP) through its four pillars: (1) Improved awareness and understanding; (2) Strengthened knowledge through surveillance and Research; (3) Support good governance and capacity building; and (4) Encourage implementation of international standards. The project strengthens coordination across the Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), the United Nations Environment Programme (UNEP) and WOAH in supporting the One Health* agenda globally, specifically in low- and middle-income countries (LMICs), where the burden of drug-resistant infection is greater. (*One Health is an integrated, unifying approach that aims to sustainably balance and optimise the health of people, animals and ecosystems. It recognises that the health of humans, domestic and wild animals, plants, and the wider environment (including ecosystems) are closely linked and interdependent.)
Fleming Fund - Commonwealth Partnerships for Antimicrobial Stewardship Scheme
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC)’s Fleming Fund to improve antimicrobial stewardship across Zambia, Tanzania, Ghana, Uganda, Sierra Leone, Kenya, Malawi and Nigeria. The partnerships leverage the expertise of UK health institutions and technical experts to strengthen the capacity of the national health workforce and institutions in partner countries to address antimicrobial resistance (AMR) challenges. The project aims to: (1) Develop partnerships between NHS Trusts (hospitals) and clinics/hospitals in low- and middle-income Commonwealth countries; (2) Share UK expertise abroad as well as bring skills and knowledge back to NHS Trusts; (3) Create focused partnerships on the theme of AMR, that includes activity on: Antimicrobial stewardship, including surveillance (AMS); Infection prevention control and antimicrobial pharmacy expertise and capacity; and (4) More generally improve the knowledge, skills and empowerment of healthcare professionals and pharmacists in partner institutions. Improving the healthcare workforce to ultimately contribute to a strengthened health system. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug-resistant infection is greater.
Fleming Fund - Multilateral Grant to the World Health Organization (WHO)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC) delivered in partnership with the World Health Organization (WHO). The project focuses on increasing the use of data on substandard and falsified (SF) medical products to tackle antimicrobial resistance (AMR) to support sustainable policies and solutions at both country and regional levels. This ‘Data for Action’ directly supports low-and middle-income countries to collect data to facilitate the Prevention, Detection and Response to Substandard and Falsified Antimicrobial Medical products through increasing the quality and quantity of data and analysis. The project also strengthens coordination with the World Organisation for Animal Health (WOAH) and other partners to support learning across human and veterinary medical products on the detection and identification of substandard and falsified medical products.
Fleming Fund - Support for Tackling Antimicrobial Resistance in Low- and Middle-Income Countries (South Centre)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC) delivered in partnership with the South Centre. The grant aims to: (1) Increase awareness of antimicrobial resistance (AMR) among high level officials and key stakeholders in LMICs; (2) Support civil society organisations (CSOs) to engage, build capacity and increase awareness on AMR, and advocate for action in government and the private sector; (3) Foster exchange and learning on AMR National Action Plan (NAP) implementation; and (4) Undertake activities in collaboration with the United Nations Food and Agriculture Organization (FAO), United Nations Environment Programme (UNEP), World Organisation for Animal Health (WOAH) and World Health Organization (WHO) and other relevant agencies at international and regional levels to support more collaboration and coordinated support on AMR, and better use of resources. Projects funded through Fleming Fund will benefit people in LMICs, where the burden of drug-resistant infection is greater.
Fleming Fund - GRAM Global Burden of Disease Project
UK - Department of Health and Social Care (DHSC)
Grant to University of Oxford/Institute of Health Metrics and Evaluation to collect, synthesise and visualise data on the burden of disease associated with anitmicrobial resistance (AMR), quantify the problem and promote policy attention and resource allocation to tackle the issue. To collect data on the burden of disease associated with antimicrobial resistance (AMR) in low- and middle-income countries (LMICs), synthesise this data, and ensure that AMR is included within the Global Burden of Disease study. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Multilateral Grant to Food and Agriculture Organisation (FAO)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC) delivered in partnership with the Food and Agriculture Organisation of the United Nations (FAO) to increase public and political awareness of antimicrobial resistance (AMR) and support countries with AMR National Action Plans. The objectives of the Fleming Fund grant with FAO are to: (1) Support development and implementation of AMR National Action Plans in 12 low- and middle-income countries (LMICs) in sub-Saharan Africa and South and South-east Asia; (2) Strengthen regulatory frameworks; (3) Increase societal awareness and understanding of AMR; (4) Develop good practices in food and agriculture sectors, and ensure these are able to be implemented in target countries; and (5) Strengthen the coordination across the World Health Organization (WHO), FAO, the United Nations Environment Programme (UNEP) and the World Organisation for Animal Health (WOAH) in supporting the One Health agenda globally, and more specifically in LMICs. Projects funded through the Fleming Fund will benefit people in LMICs, where the burden of drug-resistant infection is greater.
Fleming Fund
UK - Department of Health and Social Care (DHSC)
The Fleming Fund is a £265m commitment by the UK Government to support low- and middle-income countries to tackle antimicrobial resistance (AMR) through improving surveillance capacity. Information about individual Fleming Fund projects and contracts can be found under the "child activities" linked to this activity. The Fleming Fund aims to: 1. support the development of National Action Plans for AMR; 2. develop and support the implementation of protocols and guidance for AMR surveillance and antimicrobial use; 3. build sustainable laboratory capacity for AMR sensitivity testing and diagnosis; 4. build sustainable drug resistance surveillance capacity and networks; 5. enable the sharing of drug resistance data locally, regionally and nationally; 6. facilitate the increased use of drug resistance data to monitor and address resistance as it evolves; and 7. advocate for the application of data to promote the rationale use of antimicrobials for human health, animal health and agriculture. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
International Health Regulations (IHR) Strengthening project
UK - Department of Health and Social Care (DHSC)
The DHSC ODA-funded International Health Regulations Strengthening Project (IHR-S) provides peer to peer technical expertise through the UK Health Security Agency (UKHSA) to support public health partners to prepare, prevent, detect and respond to global health threats and increase compliance with the WHO International Health Regulations (IHR 2005). Compliance with IHR (2005) is fundamental as infectious disease outbreaks are expected to become more frequent in the future and preparedness is necessary to reduce health threats both internationally and within the UK. Lack of compliance to meet IHR (2005) requirements places countries under greater risk from disease outbreaks and other health emergencies, and has potentially wider implications on a global scale, as evidenced by the spread of Covid-19. IHR (2005) includes 13 technical areas such as surveillance, laboratories and points of entry as focal points to support countries to prevent, detect and respond to health threats. The IHR Strengthening Project has three key aims: to build technical capability, to strengthen leadership, systems and workforces, as well as to develop sustainable public health systems. IHR-S works bilaterally with four priority partner countries and three regions [including Nigeria, Pakistan, Ethiopia, Zambia, Africa (primarily through Africa CDC), the Eastern Mediterranean and Indo Pacific regions]. Over the course of this project the UK will work closely with the World Health Organization (WHO) to help it fulfil its leadership role in implementing the IHR and in responding to global public health emergencies. The project will work intimately with national governments, development partners and with regional and sub-regional agencies to deliver its support. This support will be coordinated with support from other donors, ensuring it adds value and is sustainable, identifies and responds to gaps, complements support from others and aligns behind nationally identified priorities. Implementation of UK support will be led by Public Health England, but may include contracting and working through UN agencies where appropriate and where this will maximise value for money.
Fleming Fund - Multilateral Grant to World Organisation for Animal Health (WOAH)
UK - Department of Health and Social Care (DHSC)
Contributions to the World Organisation for Animal Health (WOAH ) to improve regulatory frameworks and monitor targeting veterinary medicines. The objectives of the Fleming Fund grant with WOAH are to: 1. improve recognition of the critical importance of tacking antimicrobial resistance (AMR) and raised awareness among veterinary health professionals and the general public; 2. agree WOAH standards on AMR and progress towards implementation of these standards in low- and middle-income countries (LMICs); 3. support member states to collect and report data on the use of antimicrobial agents in animals; 4. improve regulatory frameworks targeting veterinary medicines including antimicrobials; and 5. strengthen the coordination across WHO, FAO and WOAH in supporting the One Health agenda globally, and more specifically in LMICs. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Civil society engagement through South Centre grant
UK - Department of Health and Social Care (DHSC)
Through a grant to the South Centre the Fleming Fund is seeking to increase understanding of the challenges around antimicrobial resistance (AMR) and advocate for action among governments, civil society organisations and networks in low- and middle-income countries (LMICs). The grant to the South Centre will aim to 1. support positive developments in global processes of AMR and commitments to actions on addressing AMR; 2. assist developing countries to participate positively in the global processes on AMR and to have a sense of ownership of this agenda; 3. build the knowledge base and capacity of LMICs to understand the nature and seriousness of the AMR crisis and to take policy measures and actions nationally to address this crisis; and 4. strengthen the capability of civil society groups to build awareness and take actions on AMR issues. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
World Health Organization (WHO) UK annual assessed contribution
UK - Department of Health and Social Care (DHSC)
The UK Department of Health and Social Care (DHSC) annual assessed contribution to the World Health Organization (WHO).
Fleming Fund - Multilateral Grant to World Health Organization (WHO)
UK - Department of Health and Social Care (DHSC)
Contribution to the World Health Organization (WHO) to support countries with antimicrobial resistance (AMR) National Action Plans and development of global protocols for collection of AMR data. The objectives of the Fleming Fund grant with WHO are to: 1. support countries to develop National Action Plans aligned with our regional focus in Sub-Saharan Africa, South and South-East Asia; 2. develop a One Health surveillance protocol on antimicrobial resistance focused on Escherichia coli (E. coli); 3. develop, pilot and roll out methods for antibiotic consumption and use monitoring; 4. Develop and support countries to implement of a new classification of antibiotics within the Essential Medicines List (EML) and the AWaRe categorisation to encourage rational use of antibiotics; 5. to support a deeper understanding of SF antimicrobials and their impact upon AMR; and 6. strengthen the coordination across WHO, FAO and OIE in supporting the One Health agenda globally, and more specifically in low- and middle-income countries (LMICs) Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Country and Regional Grants and Fellowships Programme
UK - Department of Health and Social Care (DHSC)
The Fleming Fund helps low- and middle-income countries to fight antimicrobial resistance. A management agent has been appointed to deliver: country grants 24 low- and middle-income countries, regional grants in West Africa, East and Southern Africa, South Asia and South East Asia, and a global fellowships programme. These initiatives aim to improve laboratory capacity and diagnosis as well as data and surveillance of antimicrobial resistance (AMR). Through the country and regional grants and the fellowships programme the Fleming Fund will: build laboratory capacity for diagnosis; collect data on drug resistance, drug quality, drug use and the burden of disease associated with AMR; enable the sharing of data relevant to AMR locally, regionally, and internationally; encourage the application of data to promote the rational use of antimicrobials; shape a sustainable system for AMR surveillance and data sharing; and increase national leadership in addressing AMR. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Commonwealth Partnerships for Antimicrobial Stewardship Scheme
UK - Department of Health and Social Care (DHSC)
A partnership programme to improve antimicrobial stewardship across Zambia, Tanzania, Ghana, Uganda, Sierra Leone, Kenya, Malawi and Nigeria. The partnerships leverage the expertise of UK health institutions and technical experts to strengthen the capacity of the national health workforce and institutions to address predefined antimicrobial resistance (AMR) challenges. The project aims to 1. Develop partnerships between NHS Trusts (hospitals) and clinics/hospitals in low- and middle-income commonwealth countries. 2. Share UK expertise abroad as well as bring skills and knowledge back to NHS Trusts. 3. Create focused partnerships on the theme of AMR, that includes activity on; Antimicrobial stewardship, including surveillance (AMS); Infection prevention control and Antimicrobial pharmacy expertise and capacity; and 4. More generally improve the knowledge, skills and empowerment of healthcare professionals and pharmacists in partner institutions. Improving the healthcare workforce to ultimately contribute to a strengthened health system. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater
Fleming Fund - Sierra Leone Country Grant (FAO Animal Health)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC). The Fleming Fund is funding an Animal Health country grant which is being delivered by the Food and Agriculture Organization of the United Nations (FAO). This grant is managed by the Fleming Fund management agent as part of the wider portfolio of country, regional and fellowship grants. The animal health grant for Sierra Leone aims to develop the foundations for Antimicrobial Resistance (AMR) and Antimicrobial Use (AMU) surveillance in the animal health sector and some aspects of AMR surveillance in the environment. Its primary objectives are to: (1) Strengthen One Health* governance and data sharing; and (2) Strengthen the AMR and AMU surveillance system in animal and environmental health. (*One Health is an integrated, unifying approach that aims to sustainably balance and optimise the health of people, animals and ecosystems. It recognises that the health of humans, domestic and wild animals, plants, and the wider environment (including ecosystems) are closely linked and interdependent.)
Fleming Fund - Zimbabwe Country Grant (FAO)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC). The Fleming Fund country grant to Zimbabwe is being delivered by the Food and Agriculture Organization of the United Nations (FAO). This grant is managed by the Fleming Fund management agent as part of the wider portfolio of country, regional and fellowship grants. However, as the grant is delivered by FAO the grant has been signed directly with DHSC. The grant continues to support improved clinical services in hospitals, generating more and better data on antimicrobial resistance (AMR), including data on antimicrobial use, to feed into improved stewardship and appropriate use of antibiotics.
Fleming Fund - Sierra Leone Country Grant (WHO – Human Health)
UK - Department of Health and Social Care (DHSC)
This is an Official Development Assistance (ODA) funded UKaid programme from the Department of Health and Social Care (DHSC). The Fleming Fund Human Health country grant in Sierra Leone is being delivered by the World Health Organization (WHO). This grant is managed by the Fleming Fund management agent as part of the wider portfolio of country, regional and fellowship grants. It aims to develop a robust diagnostic stewardship programme, increasing the data collected, analysed, and used. At the national level, it will integrate antimicrobial resistance (AMR) surveillance into other areas of work at sector and integrated surveillance levels. Efforts will be made to increase workforce capacity to perform advanced microbiology testing techniques. In addition, coordination will be strengthened following One Health* principles, and practitioner engagement and policy initiatives will be implemented to encourage the use of AMR data. (*One Health is an integrated, unifying approach that aims to sustainably balance and optimise the health of people, animals and ecosystems. It recognises that the health of humans, domestic and wild animals, plants, and the wider environment (including ecosystems) are closely linked and interdependent.)
Fleming Fund - Independent Evaluation
UK - Department of Health and Social Care (DHSC)
The independent evaluation will assess how far the outputs of the portfolio of Fleming Fund country and regional grants, and the Fleming Fellowships contribute to the outcomes and impact identified by the Department of Health and Social Care (DHSC). Six specific evaluation questions were agreed during the inception phase for the evaluation. In answering these six questions, the evaluation intends to meet two objectives: 1. In 2019, the evaluation will generate learning to inform course correction and adaptation in the present phase of support; 2. In late 2020, the evaluation’s focus will shift to providing an independent summative judgement of the Fund’s results and achievements. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
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