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Fleming Fund - GRAM Global Burden of Disease Project
UK - Department of Health and Social Care (DHSC)
Grant to University of Oxford/Institute of Health Metrics and Evaluation to collect, synthesise and visualise data on the burden of disease associated with anitmicrobial resistance (AMR), quantify the problem and promote policy attention and resource allocation to tackle the issue. To collect data on the burden of disease associated with antimicrobial resistance (AMR) in low- and middle-income countries (LMICs), synthesise this data, and ensure that AMR is included within the Global Burden of Disease study. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Independent Evaluation
UK - Department of Health and Social Care (DHSC)
The independent evaluation will assess how far the outputs of the portfolio of Fleming Fund country and regional grants, and the Fleming Fellowships contribute to the outcomes and impact identified by the Department of Health and Social Care (DHSC). Six specific evaluation questions were agreed during the inception phase for the evaluation. In answering these six questions, the evaluation intends to meet two objectives: 1. In 2019, the evaluation will generate learning to inform course correction and adaptation in the present phase of support; 2. In late 2020, the evaluation’s focus will shift to providing an independent summative judgement of the Fund’s results and achievements. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Contribution to the International Reference Centre for Antimicrobial Resistance
UK - Department of Health and Social Care (DHSC)
The Fleming Fund contribution to a UK draw-down service for technical assistance, training and quality assurance for low and middle income countries to support antimicrobial resistance (AMR) surveillance system building across all one-health sectors. The objectives of the reference centre are to: 1. Develop capacity of low- and middle-income countries (LMICs) for surveillance of AMR and antimicrobial use (AMU) through residential AMR training workshops, country visits to partners to offer training, provision of proficiency testing schemes; 2. Strengthen governance related to AMU and AMR by providing expert advice on new or emerging resistances that present a threat to animal or public health, providing expert advice on how to bench-mark capability and the authorisation of antibiotics and providing verification testing at our UK laboratories; 3. Promote good agricultural practices and prudent use of antimicrobials by providing advice and support for the adaptation and implementation of alternatives to antibiotics; and 4. Raise awareness of AMR by publishing and contributing to expert reports and peer-reviewed scientific manuscripts. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater
Fleming Fund - Multilateral Grant to Food and Agriculture Organisation (FAO)
UK - Department of Health and Social Care (DHSC)
Contribution to the Food and Agriculture Organisation (FAO) to increase public and political awareness of antimicrobial resistance (AMR) and support countries with AMR National Action Plans. The objectives of the Fleming Fund grant with FAO are to: 1. support development and implementation of AMR National Action Plans in 12 low- and middle-income countries (LMICs) in sub-Saharan Africa and South and South-east Asia; 2. strengthen regulatory frameworks; 3. increase societal awareness and understanding of AMR; 4. develop good practices in food and agriculture sectors, and ensure these are able to be implemented in target countries; and 5. strengthen the coordination across WHO, FAO and OIE in supporting the One Health agenda globally, and more specifically in LMICs. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Multilateral Grant to World Health Organization (WHO)
UK - Department of Health and Social Care (DHSC)
Contribution to the World Health Organization (WHO) to support countries with antimicrobial resistance (AMR) National Action Plans and development of global protocols for collection of AMR data. The objectives of the Fleming Fund grant with WHO are to: 1. support countries to develop National Action Plans aligned with our regional focus in Sub-Saharan Africa, South and South-East Asia; 2. develop a One Health surveillance protocol on antimicrobial resistance focused on Escherichia coli (E. coli); 3. develop, pilot and roll out methods for antibiotic consumption and use monitoring; 4. Develop and support countries to implement of a new classification of antibiotics within the Essential Medicines List (EML) and the AWaRe categorisation to encourage rational use of antibiotics; 5. to support a deeper understanding of SF antimicrobials and their impact upon AMR; and 6. strengthen the coordination across WHO, FAO and OIE in supporting the One Health agenda globally, and more specifically in low- and middle-income countries (LMICs) Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Country and Regional Grants and Fellowships Programme
UK - Department of Health and Social Care (DHSC)
The Fleming Fund helps low- and middle-income countries to fight antimicrobial resistance. A management agent has been appointed to deliver: country grants 24 low- and middle-income countries, regional grants in West Africa, East and Southern Africa, South Asia and South East Asia, and a global fellowships programme. These initiatives aim to improve laboratory capacity and diagnosis as well as data and surveillance of antimicrobial resistance (AMR). Through the country and regional grants and the fellowships programme the Fleming Fund will: build laboratory capacity for diagnosis; collect data on drug resistance, drug quality, drug use and the burden of disease associated with AMR; enable the sharing of data relevant to AMR locally, regionally, and internationally; encourage the application of data to promote the rational use of antimicrobials; shape a sustainable system for AMR surveillance and data sharing; and increase national leadership in addressing AMR. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund
UK - Department of Health and Social Care (DHSC)
The Fleming Fund is a £265m commitment by the UK Government to support low- and middle-income countries to tackle antimicrobial resistance (AMR) through improving surveillance capacity. Information about individual Fleming Fund projects and contracts can be found under the "child activities" linked to this activity. The Fleming Fund aims to: 1. support the development of National Action Plans for AMR; 2. develop and support the implementation of protocols and guidance for AMR surveillance and antimicrobial use; 3. build sustainable laboratory capacity for AMR sensitivity testing and diagnosis; 4. build sustainable drug resistance surveillance capacity and networks; 5. enable the sharing of drug resistance data locally, regionally and nationally; 6. facilitate the increased use of drug resistance data to monitor and address resistance as it evolves; and 7. advocate for the application of data to promote the rationale use of antimicrobials for human health, animal health and agriculture. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
International Health Regulations (IHR) Strengthening project
UK - Department of Health and Social Care (DHSC)
The DHSC ODA-funded International Health Regulations Strengthening Project (IHR-S) provides peer to peer technical expertise through the UK Health Security Agency (UKHSA) to support public health partners to prepare, prevent, detect and respond to global health threats and increase compliance with the WHO International Health Regulations (IHR 2005). Compliance with IHR (2005) is fundamental as infectious disease outbreaks are expected to become more frequent in the future and preparedness is necessary to reduce health threats both internationally and within the UK. Lack of compliance to meet IHR (2005) requirements places countries under greater risk from disease outbreaks and other health emergencies, and has potentially wider implications on a global scale, as evidenced by the spread of Covid-19. IHR (2005) includes 13 technical areas such as surveillance, laboratories and points of entry as focal points to support countries to prevent, detect and respond to health threats. The IHR Strengthening Project has three key aims: to build technical capability, to strengthen leadership, systems and workforces, as well as to develop sustainable public health systems. IHR-S works bilaterally with four priority partner countries and three regions [including Nigeria, Pakistan, Ethiopia, Zambia, Africa (primarily through Africa CDC), the Eastern Mediterranean and Indo Pacific regions]. Over the course of this project the UK will work closely with the World Health Organization (WHO) to help it fulfil its leadership role in implementing the IHR and in responding to global public health emergencies. The project will work intimately with national governments, development partners and with regional and sub-regional agencies to deliver its support. This support will be coordinated with support from other donors, ensuring it adds value and is sustainable, identifies and responds to gaps, complements support from others and aligns behind nationally identified priorities. Implementation of UK support will be led by Public Health England, but may include contracting and working through UN agencies where appropriate and where this will maximise value for money.
Fleming Fund - Multilateral Grant to World Organisation for Animal Health (WOAH)
UK - Department of Health and Social Care (DHSC)
Contributions to the World Organisation for Animal Health (WOAH ) to improve regulatory frameworks and monitor targeting veterinary medicines. The objectives of the Fleming Fund grant with WOAH are to: 1. improve recognition of the critical importance of tacking antimicrobial resistance (AMR) and raised awareness among veterinary health professionals and the general public; 2. agree WOAH standards on AMR and progress towards implementation of these standards in low- and middle-income countries (LMICs); 3. support member states to collect and report data on the use of antimicrobial agents in animals; 4. improve regulatory frameworks targeting veterinary medicines including antimicrobials; and 5. strengthen the coordination across WHO, FAO and WOAH in supporting the One Health agenda globally, and more specifically in LMICs. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Civil society engagement through South Centre grant
UK - Department of Health and Social Care (DHSC)
Through a grant to the South Centre the Fleming Fund is seeking to increase understanding of the challenges around antimicrobial resistance (AMR) and advocate for action among governments, civil society organisations and networks in low- and middle-income countries (LMICs). The grant to the South Centre will aim to 1. support positive developments in global processes of AMR and commitments to actions on addressing AMR; 2. assist developing countries to participate positively in the global processes on AMR and to have a sense of ownership of this agenda; 3. build the knowledge base and capacity of LMICs to understand the nature and seriousness of the AMR crisis and to take policy measures and actions nationally to address this crisis; and 4. strengthen the capability of civil society groups to build awareness and take actions on AMR issues. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Commonwealth Partnerships for Antimicrobial Stewardship Scheme
UK - Department of Health and Social Care (DHSC)
A partnership programme to improve antimicrobial stewardship across Zambia, Tanzania, Ghana, Uganda, Sierra Leone, Kenya, Malawi and Nigeria. The partnerships leverage the expertise of UK health institutions and technical experts to strengthen the capacity of the national health workforce and institutions to address predefined antimicrobial resistance (AMR) challenges. The project aims to 1. Develop partnerships between NHS Trusts (hospitals) and clinics/hospitals in low- and middle-income commonwealth countries. 2. Share UK expertise abroad as well as bring skills and knowledge back to NHS Trusts. 3. Create focused partnerships on the theme of AMR, that includes activity on; Antimicrobial stewardship, including surveillance (AMS); Infection prevention control and Antimicrobial pharmacy expertise and capacity; and 4. More generally improve the knowledge, skills and empowerment of healthcare professionals and pharmacists in partner institutions. Improving the healthcare workforce to ultimately contribute to a strengthened health system. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater
World Health Organization (WHO) UK annual assessed contribution
UK - Department of Health and Social Care (DHSC)
The UK Department of Health and Social Care (DHSC) annual assessed contribution to the World Health Organization (WHO).
Fleming Fund - Multi Party Trust Fund for Antimicrobial Resistance (AMR MPTF)
UK - Department of Health and Social Care (DHSC)
Contribution to the United Nations Multi Party Trust Fund (MPTF) for AMR - the joint funding mechanism for FAO, OIE and WHO Tripartite over an initial five-year period (2019-2024). The MPTF seeks to promote increased integration and coordination within the tripartite and promote One Health action to tackle AMR.
Fleming Fund - Contribution to the International Reference Centre for Antimicrobial Resistance
UK - Department of Health and Social Care (DHSC)
The Fleming Fund contribution to a UK draw-down service for technical assistance, training and quality assurance for low and middle income countries to support antimicrobial resistance (AMR) surveillance system building across all one-health sectors. The objectives of the reference centre are to: 1. Develop capacity of low- and middle-income countries (LMICs) for surveillance of AMR and antimicrobial use (AMU) through residential AMR training workshops, country visits to partners to offer training, provision of proficiency testing schemes; 2. Strengthen governance related to AMU and AMR by providing expert advice on new or emerging resistances that present a threat to animal or public health, providing expert advice on how to bench-mark capability and the authorisation of antibiotics and providing verification testing at our UK laboratories; 3. Promote good agricultural practices and prudent use of antimicrobials by providing advice and support for the adaptation and implementation of alternatives to antibiotics; and 4. Raise awareness of AMR by publishing and contributing to expert reports and peer-reviewed scientific manuscripts. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater
The effectiveness, mechanisms of change, and acceptability of Family Focused PsychoSocial Support (FFPSS) for at-risk adolescents in Lebanon
DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY
This mixed-method study is an international collaboration between the American University of Beirut and War Child Holland, supported by project partners the Danish Refugee Council and Terre des Hommes Italy, the Ministry of Public Health Lebanon, UNICEF, and international expertise from University College Dublin, the Boston College School of Social Work, and Queen's University Belfast. The study aims to develop and test a culturally and contextually sensitive Systemic Family Intervention Module for at-risk adolescents that can be run alongside existing focused psychosocial programmes in Lebanon. Focused psychosocial support aims to promote wellbeing and resilience and to reduce mental ill-health in young people at risk of child protection violations, including gender-based violence, child marriage, and child labour. One in five children globally live in conflict affected areas, and these children experience a high incidence of mental disorders. The global burden of disease for mental disorders is 5 times higher in conflict-affected areas than the global average. Young people are affected not only by the violence, loss, and insecurity of war, but the systemic impact on their living conditions, access to school and health care, structural discrimination, and gender-based violence, as well as their caregivers trauma, stress, and compromised parenting capacity. The devastating impact of war, conflict, and extreme adversity on the mental health and wellbeing of children and adolescents has been extensively researched, but with continuing challenges in improving the quality and scope of interventions for these populations. The treatment gap in low resourced settings is as high as 90%, with major barriers of limited infrastructure and trained specialists. As a strategy to close this gap, psychosocial support interventions as part of a stepped care coordinated approach have been developed and widely implemented. There is a small but growing evidence base for psychosocial interventions in conflict and humanitarian emergencies, however adolescent mental health and family-based interventions are drastically under-researched and under-resourced. Nurturing family environments are essential for healthy child development, and parenting and systemic family interventions in other populations and country settings show strong effectiveness for both mental health and protection outcomes. This study therefore aims to develop and evaluate a Family Systemic Intervention Module to use alongside UNICEF Lebanon's focused psychosocial support programme, to enhance current humanitarian programming and addressing a significant weakness of the current evidence base for at-risk adolescents and their families in conflict-affected contexts. Findings will inform the Mental Health System Reform in Lebanon led by the National Mental Health Programme of the Ministry of Public Health. Lebanon is a middle-income country, home to an estimated 1.5 million refugees in a population of around 5.9 million. The majority of refugees come from Syria, as well as almost half a million Palestinian refugees. Almost 60% of Syrian refugees are living in extreme poverty, unable to meet basic survival needs, whilst 30% of Lebanese host communities also live below the poverty line. The many social and economic pressures facing these populations increases the risk of child protection issues, through sexual and gender-based violence, domestic violence, child marriage, child labour and recruitment intro armed groups. In 2015, a 5-year Mental Health and Substance Use strategy for Lebanon 2015-2020 was launched with the aim of reforming the Mental Health System, and whilst much has been achieved, there remains a gap in the provision of family systemic interventions. Lebanon is therefore an ideal location for this study because it has both large vulnerable populations in need of focused support, as well as political will to integrate learning into the national mental health strategy.
ARUA CoE in Materials, Energy & Nanotechnology Research.
DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY
Under the theme of Energy, Materials Development and Nanotechnology, ARUA CoE-MEN will use materials and nanotechnology to develop energy solutions for Africa, as well as materials development for efficiency and sustainability, and also develop personnel. The main aim is to develop materials and new technologies to benefit Africa, in both infrastructure and human development, to enable global competition. There will be a range of projects around the technological use of materials, from fundamental to devices up to prototype level and application. The projects should help to identify, and later develop, new opportunities in an African context. This is necessary because often solutions from more temperate climates cannot withstand the harsher conditions in Africa (higher temperatures and humidity), and so are not suitable. This will facilitate the development of new opportunities in an African context (e.g. sustainable manufacturing, off-grid energy technologies, improved materials, and materials recycling - obtaining more useful materials, as well as removing waste), developing the people to do it, and to help Africa become more competitive. ARUA CoE-MEN will investigate barriers to upscaling and uptake of sustainable technologies in Africa. As well as improving materials, strategies for creating and encouraging new technological pathways to facilitate transitions to sustainability in emerging water and energy technologies will be explored. Improved energy security will help the economies develop, leading to more stability with jobs, facilite people to become entrepreneurs, and help to improve the welfare and the wealth of citizens in the different countries. Some of projects target efficiency of materials and hence safety, e.g. by improving buildings and infrastructure (recent flood damage in southern Africa has shown that houses need to be more robust). Improved materials could have even larger long-term benefits on the environment, and help to improve other living conditions, e.g. improving water storage efficiency and cleanliness by combatting corrosion. The potential benefit to the African countries is improved development, improved environments and better education, for researchers and more widely, for the public, by outreach. ARUA CoE-MEN will also try to support more part-time higher degree students, who struggle to balance work, family and their research. This is an untapped source of students, and is an opportunity to increase the skills and work more closely with industry, and possibly entrepreneurs. The benefit to the UK is the strengthening of ties with the different African countries involved, and the potential to enter into business relationships for manufacturing in the future. The hub will be at the University of the Witwatersrand, which has a long-term history of running very successful networks and groups in materials science, and also provides world-class equipment and infrastructure to be shared.
Tackling Maternal and Child Undernutrition Programme- Phase II
UK - Foreign, Commonwealth Development Office (FCDO)
To contribute towards improved health and nutrition status for children under two years measured primarily by a reduction in stunting by 2023.
Investing in Human Capital through Partnerships Beyond Aid in the Social Sectors Programme
UK - Foreign, Commonwealth Development Office (FCDO)
To improve governance and accountability in education, health and social protection sectors and contribute to policy and research which will inform interventions to improve equity and reduce poverty.
UK-SA Health Systems Strengthening Partnerships Programme
UK - Foreign, Commonwealth Development Office (FCDO)
Support to strengthen South Africa’s health systems to achieve Universal Health Coverage, and drive collaboration on pandemic preparedness
Securing global wheat crops for food and nutritional security - in partnership with the Bill & Melinda Gates Foundation (BMGF)
UK - Foreign, Commonwealth Development Office (FCDO)
Working in partnership with the Bill & Melinda Gates Foundation on two major co-investments in wheat crop improvement, DFID’s funding will increase the nutritional quality and disease resistance of wheat crops, building the resilience of smallholder farmers in Sub-Saharan Africa and South Asia, and contributing to global food security in the face of climate change, and emerging plant disease and pest threats. Securing global wheat crops through wheat breeding includes improving heat tolerance and increasing climate resilience in the crop varieties.
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