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UK Vaccine Network - Vaccine Development Competition

UK - Department of Health (DH)

The Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified a range of human diseases with epidemic potential in low and middle income countries for which the development of Vaccine Products is a priority. The Department of Health and Social Care is collaborating with Innovate UK (an arms’ length body of the Department of Business, Energy and Industrial Strategy) in running this competition. Innovate UK has considerable expertise in running competitions of this nature. The competition was open to all organisations that were able to demonstrate that their product or work has a realistic route to market, whether in the short or long term, and is primarily for the benefit of low and middle income countries. Successful projects were awarded a research contract wholly funded by the Department of Health and Social Care and administered by Innovate UK. The Department of Health and Social Care made up to £11,323,617 available to run the competition and fund the successful projects.

Project identifier:

GB-GOV-10-UKVN-VD-IUK

Start Date:

2016-02-01

Activity Status:

Implementation

Total Budget:

£11,067,143.70


UK Vaccine Network - Clinical Vaccine Development Competition

UK - Department of Health (DH)

The Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified a range of human diseases with epidemic potential in low and middle income countries for which the development of Vaccine Products is a priority. The Department of Health and Social Care is collaborating with Innovate UK (an arms’ length body of the Department of Business, Energy and Industrial Strategy) in running this competition. Innovate UK has considerable expertise in running competitions of this nature. The competition was open to all organisations that were able to demonstrate that their product or work has a realistic route to market, whether in the short or long term, and is primarily for the benefit of low and middle income countries. Successful projects were awarded a research contract wholly funded by the Department of Health and Social Care and administered by Innovate UK. The Department of Health and Social Care made up to £35 million available to run the competition and fund the successful projects.

Project identifier:

GB-GOV-10-UKVN-CVD-IUK

Start Date:

2017-01-01

Activity Status:

Implementation

Total Budget:

£30,138,767.56


UK Public Health Rapid Support Team - Research

UK - Department of Health (DH)

""Created in 2016, the UK-PHRST is the primary arm of Her Majesty’s Government to provide and coordinate the UK’s public health response to outbreaks in LMICs. The UK-PHRST is a unique collaboration between Public Health England and the London School of Hygiene and Tropical Medicine with input from a number of academic partners. The UK-PHRST’s remit covers outbreak response, research, and capacity building, as components of its integrated triple mandate: • Rapidly investigate and respond to disease outbreaks at their source in LMICs eligible for UK Official Development Assistance (ODA), with the aim of stopping a public health threat from becoming a broader health emergency • Conduct research to generate an evidence base for best practice in epidemic preparedness and response • Build capacity for improved and rapid national response to disease outbreaks in LMICs and contribute to supporting implementation of IHR at the request of national governments or international stakeholders such as WHO. The UK-PHRST rapidly deploys a standing team of multidisciplinary public health professionals and researchers as required in countries that are a priority for the UK’s ODA programme. The UK-PHRST full-time Core Deployable Team consists of specialists in epidemiology, laboratory microbiology, infection prevention and control, clinical case management and clinical research, social science, data management and logistical support who are available to deploy within 48 of an approved request. Reservists and Field Epidemiology Training Programme (FETP) Fellows complement this team, providing surge capacity and specialist expertise when needed. The UK-PHRST is financed through UK Official Development Assistance (ODA) funding through the Department of Health and Social Care. The UK-PHRST Director is the accountable person to the UK Government, through PHE, for delivery of the UK-PHRST objectives.""

Project identifier:

GB-GOV-10-UKPHRST-LSHTM

Start Date:

2016-04-01

Activity Status:

Implementation

Total Budget:

£3,445,469.78


UK Public Health Rapid Support Team - Rapid investigation and response

UK - Department of Health (DH)

Created in 2016, the UK-PHRST is the primary arm of Her Majesty’s Government to provide and coordinate the UK’s public health response to outbreaks in LMICs. The UK-PHRST is a unique collaboration between Public Health England and the London School of Hygiene and Tropical Medicine with input from a number of academic partners. The UK-PHRST’s remit covers outbreak response, research, and capacity building, as components of its integrated triple mandate: • Rapidly investigate and respond to disease outbreaks at their source in LMICs eligible for UK Official Development Assistance (ODA), with the aim of stopping a public health threat from becoming a broader health emergency • Conduct research to generate an evidence base for best practice in epidemic preparedness and response • Build capacity for improved and rapid national response to disease outbreaks in LMICs and contribute to supporting implementation of IHR at the request of national governments or international stakeholders such as WHO. The UK-PHRST rapidly deploys a standing team of multidisciplinary public health professionals and researchers as required in countries that are a priority for the UK’s ODA programme. The UK-PHRST full-time Core Deployable Team consists of specialists in epidemiology, laboratory microbiology, infection prevention and control, clinical case management and clinical research, social science, data management and logistical support who are available to deploy within 48 of an approved request. Reservists and Field Epidemiology Training Programme (FETP) Fellows complement this team, providing surge capacity and specialist expertise when needed. The UK-PHRST is financed through UK Official Development Assistance (ODA) funding through the Department of Health and Social Care. The UK-PHRST Director is the accountable person to the UK Government, through PHE, for delivery of the UK-PHRST objectives.

Project identifier:

GB-GOV-10-UKPHRST-PHE

Start Date:

2016-04-01

Activity Status:

Implementation

Total Budget:

£10,803,533.65


UK Vaccine Network - Preclinical Vaccine Development Competition

UK - Department of Health (DH)

The Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified a range of human diseases with epidemic potential in low and middle income countries for which the development of Vaccine Products is a priority. The Department of Health and Social Care is collaborating with Innovate UK (an arms’ length body of the Department of Business, Energy and Industrial Strategy) in running this competition. Innovate UK has considerable expertise in running competitions of this nature. The competition was open to all organisations that were able to demonstrate that their product or work has a realistic route to market, whether in the short or long term, and is primarily for the benefit of low and middle income countries. Successful projects were awarded a research contract wholly funded by the Department of Health and Social Care and administered by Innovate UK. The Department of Health and Social Care made up to £24,719,293 available to run the competition and fund the successful projects.

Project identifier:

GB-GOV-10-UKVN-PVD-IUK

Start Date:

2016-10-01

Activity Status:

Implementation

Total Budget:

£25,001,593.32


UK Vaccine Network - One Health Vaccinology Competition

UK - Department of Health (DH)

The former Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified that many pathogens of epidemic potential are zoonotic (having both human and animal hosts) and therefore a One Health approach is essential to tackle these diseases. The Department of Health and Social Care has collaborated with Biotechnology and Biological Sciences Research Council (BBSRC) (a non-departmental public body principally funded through the Science Budget by the Department of Business, Energy and Industrial Strategy, BEIS), to run a research competition to support One Health Approaches to Accelerate Vaccine Development. This call was wholly funded by ODA and therefore the primary purpose of all funded research must be to support the economic development and welfare of countries on the Development Assistance Committee list. Five successful projects were awarded a research grant by BBSRC, wholly funded by the Department of Health and Social Care. Just under £5.5million funding was made available to BBSRC to fund these successful projects under the provisions of the International Development Act 2002. These projects are managed by BBSRC.

Project identifier:

GB-GOV-10-UKVN-BBSRC

Start Date:

2017-07-01

Activity Status:

Implementation

Total Budget:

£4,197,463.41


Global Antimicrobial Resistance Innovation Fund (GAMRIF) - UK-China: Innovation and Collaboration to tackle AMR

UK - Department of Health (DH)

The UK Department of Health and Social Care (DHSC)'s UK-China research competition supports new innovations to address anti-microbial resistance (AMR) in both humans and animals, which together constitute a significant threat to human health. Successful projects are a partnership of UK companies and research organisations, with Chinese companies and research organisations. £10 million of UK aid funding has now been awarded to UK partners through delivery partner Innovate UK, with the Chinese Ministry of Science and Technology (MoST) providing funding for the Chinese partners who will receive up to a total of 60 million RMB. The output of these partnerships will benefit people in other low- and middle-income countries (LMICs) around the world.

Project identifier:

GB-GOV-10-GAMRIF-WP1-UK-CHINA

Start Date:

2017-01-01

Activity Status:

Implementation

Total Budget:

£10,494,540.56


UK Vaccine Network - Future Vaccine Manufacturing Research Hub Competition

UK - Department of Health (DH)

The Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified a range of human diseases with epidemic potential in low and middle income countries (LMICs) for which the development of Vaccine Products is a priority. The UKVN also advised that research to improve vaccine manufacturing should be a priority. The Department of Health and Social Care collaborated with the Engineering and Physical Sciences Research Council (EPSRC) (a non-departmental public body principally funded through the Science Budget by the Department of Business, Energy and Industrial Strategy) to run the Future Vaccine Manufacturing Research Hub competition. The competition was open to all eligible research organisations that could demonstrate that their work would contribute towards Vaccine Manufacturing Research specifically for the benefit of LMICs. £17million of funding was made available to EPSRC to fund two successful projects. This funding was provided under the provisions of the International Development Act 2002.

Project identifier:

GB-GOV-10-UKVN-FVMRH-EPSRC

Start Date:

2017-01-24

Activity Status:

Implementation

Total Budget:

£16,915,750.14


UK Partnering for Accelerated Climate Transitions (UK PACT)

UK - Department for Business, Energy and Industrial Strategy (BEIS)

UK Partnering for Accelerated Climate Transitions (UK PACT) is the Department for Business, Energy, and Industrial Strategy’s (BEIS) flagship technical assistance programme and is funded via the UK’s International Climate Finance (ICF) commitment. UK PACT operates in countries with high greenhouse gas emissions that are eligible to receive Official Development Assistance (ODA) and have potential for high emissions reduction. UK PACT supports these countries to increase and implement their ambitions for emissions reductions in line with internationally agreed commitments (NDCs). UK PACT works strategically to leverage the UK’s position as a global leader in tackling climate change to provide support and share expertise, build strong relationships with other governments, and deliver transformational assistance

Project identifier:

GB-GOV-13-ICF-0021-UKPACT

Start Date:

2018-02-01

Activity Status:

Implementation

Total Budget:

£70,000,000


UK Climate Investments (UKCI)

UK - Department for Business, Energy and Industrial Strategy (BEIS)

UK Climate Investments (UKCI) invests in renewable energy and energy efficiency projects across sub-Saharan Africa and India to demonstrate that low carbon development is possible, replicable at scale, commercially viable and capable of lowering carbon emissions and supporting economic growth. The fund (£200m of UK International Climate Finance) provides late-stage minority equity investments on a commercial basis to get projects off the ground that would not otherwise reach financial close

Project identifier:

GB-GOV-13-ICF-0015-UKCI

Start Date:

2015-06-01

Activity Status:

Implementation

Total Budget:

£96,680,162


World Health Organization (WHO) UK annual assessed contribution

UK - Department of Health (DH)

The UK Department of Health and Social Care (DHSC) annual assessed contribution to the World Health Organization (WHO).

Project identifier:

GB-GOV-10-WHO_UK_contribution

Start Date:

2015-01-01

Activity Status:

Implementation

Total Budget:

£72,960,000


UK Collaborative on Development Research (UCKDR) annual contribution

UK - Department of Health (DH)

The Department of Health and Social Care (DHSC) provides a funding contribution to the UK Collaborative on Development Research (UKCDR), a neutral and impartial entity governed by the Strategic Coherence of ODA-funded Research (SCOR) Board. UKCDR provide high-level coherence for UK Official Development Assistance (ODA) research.

Project identifier:

GB-GOV-10-Wellcome_UKCDR

Start Date:

2019-07-29

Activity Status:

Implementation

Total Budget:

£344,000


UK Vaccine Network

UK - Department of Health (DH)

The UK Vaccine Network project is a £110 million ODA-funded project which makes targeted investments to support the development of new vaccines and vaccine technologies for emergent infectious disease threats in low and middle-income countries. This will allow outbreaks of diseases with epidemic potential to either be prevented through proactive vaccination campaigns or controlled through quick development of new vaccines and/or responsive vaccination campaigns upon outbreak detection. An investment strategy for the project was developed using advice from the UK Vaccine Network, a group of experts from academia, industry, government and philanthropic organisations, chaired by the DHSC Chief Scientific Adviser

Project identifier:

GB-GOV-10-UKVN

Start Date:

2016-02-01

Activity Status:

Implementation

Total Budget:

£106,462,002.69


UK Vaccine Network - MRC/BBSRC Intramural Centre Vaccine Development Projects

UK - Department of Health (DH)

The Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified a range of human diseases with epidemic potential in low and middle income countries (LMICs) for which the development of Vaccine Products is a priority. The Department of Health and Social Care collaborated with the Biotechnology and Biological Sciences Research Council and the Medical Research Council, both arms' length bodies of the Department of Business, Energy and Industrial Strategy, in running the 2016 competition which aims to support vaccine research to tackle UKVN-identified priority pathogens. This competition was wholly funded by Official Development Assistance and therefore projects must be primarily for the benefit of LMICs. The successful projects are being managed by the National Institute for Health Research. The Department of Health and Social Care made around £12 million available to fund six successful projects.

Project identifier:

GB-GOV-10-UKVN-NETSCC

Start Date:

2016-09-01

Activity Status:

Implementation

Total Budget:

£14,376,788.96


UK Vaccine Network - Epidemiology for Vaccinology Competition

UK - Department of Health (DH)

The former Prime Minister established the UK Vaccine Network in June 2015 to ensure that the UK was at the forefront of the global fight against future disease outbreaks. The UK Vaccine Network has identified that alongside the need for Vaccine Products, there is also a need for the development of epidemiological models, and for tools and technologies to assist with the deployment and clinical trialling of vaccines in outbreak situations in low and middle income countries. The Department of Health and Social Care worked alongside the National Institute for Health Research to run a research competition to fund such research. The call was open to all eligible researchers that could demonstrate that their work was within the scope of the call and would positively support the welfare and economic development of countries on the OECD DAC list. The Department of Health and Social Care made up to £5 million available to run the competition and fund successful projects, under the provisions of the International Development Act 2002. Five successful projects have been awarded a research contract.

Project identifier:

GB-GOV-10-UKVN-EFV-CCF

Start Date:

2018-04-01

Activity Status:

Implementation

Total Budget:

£4,764,495.60


Fertile Land From Fertile Seas

UK - Department for Business, Energy and Industrial Strategy (BEIS)

One of Mexico's most important sources of employment and revenue, and the world's second largest coral reef chain, are under threat from constant bombardment by invasive seaweed. According to the World Travel & Tourism Council (WTTC), in 2018 tourism contributed 17.2% of the country's GDP (GDP 2018=$1,223B) and >9 million jobs (17% of all jobs in the country). About half of Mexico's tourism income and jobs are generated in its Caribbean coast, where a record-breaking 550km-long mass of rotting Sargassum biomass is currently heading. The impact is estimated to be a 30% decrease in tourism revenue in affected areas. This project will take Sargassum and Macrocystis from Mexico's Caribbean and Pacific coastlines, respectively, and evaluate methods for subcritical water processing leading to production of liquid and solid fertiliser products which meet the requirements necessary for commercialisation. We will evaluate the economics and sustainability of producing such fertilisers from invasive and non-invasive macroalgae. The project's interdisciplinary consortium incorporates UK and Mexico biological, ecosystem management and chemical engineering expertise. Our previous Newton funded project successfully developed a microalgae-based biostimulant product, enabling more sustainable crop growth enhancement for Mexico's growing agricultural industry. This new project takes much of these learnings and expertise (product testing, optimisation and development) and applies them to solving Mexico's macroalgae (seaweed) problem. We will develop a process that removes the damaging seaweed build up and transforms a highly costly problem into a valuable and sustainable agricultural product. This will have a significant positive impact for Mexico's important tourism industry and its marine ecosystem. Furthermore, this technology will help develop Mexico's still small but established macroalgae industry and provide important information to inform industry policies and regulations. The overall aim of this project is to test the feasibility of using sub-critical water processing methods in the conversion of Mexico's problematic seaweed bloom biomass to agricultural fertiliser and assess the sustainability of production using invasive and non-invasive macroalgae. We aim to market test fertiliser products within 18 months, with full commercial deployment within 3 years.

Project identifier:

GB-GOV-13-FUND--Newton-BB_V003755_1

Start Date:

2020-05-14

Activity Status:

Implementation

Total Budget:

£0


Enhancing collaboration between state, civil society and community in the face of crime and chronic violence in Mexico

UK - Department for Business, Energy and Industrial Strategy (BEIS)

We will build on the findings of 2 previous Newton projects, one led by UK and Mexico leads Stack and Maldonado and the other by partner Pearce, to enhance collaboration between state, civil society and communities in security policy and practice, with a view to counteracting the tendency across Mexico for violence, already exacerbated by crime, to become ""chronic"" (Pearce) in every sphere of life. In August, Silvano Aureoles, head of the state governors' body, and governor of Michoacán, where both teams conducted fieldwork, pledged to respond to unabated violence by ""reinforcing the strategies of capture of criminal objectives and the dismantling of their structures"", emphasizing inter-institutional collaboration. Aureoles did not mention that the dismantling of a criminal organization in Michoacán in 2014 was followed by further violence, lasting through our research in 2016-19, despite improving inter-institutional collaboration. Aureoles has also called for civil society and communities to collaborate with government, but he has fallen back on models that, our projects showed, fail to generate the effective collaboration that can reduce crime and violence. Similarly, President López Obrador's team hosted Peace and Reconciliation Forums in 2018, but these largely failed to engage communities, and he is now accused of reproducing old models of security policy. Our Newton projects studied diverse collaborative processes in Michoacán, enabling us now to enhance those processes through knowledge exchange with local and national partners, and where appropriate to initiate new ones. We will extend the impact to 2 other afflicted states, Jalisco and Veracruz, where we have new academic and non-academic partners with complementary expertise. We will articulate flexible principles and strategies for collaboration suited to regional contexts, which can thus be applied across Mexico, helping to achieve security policy and practice that is fit for context and purpose.

Project identifier:

GB-GOV-13-FUND--Newton-ES_V002805_1

Start Date:

2020-05-01

Activity Status:

Implementation

Total Budget:

£0


Megacity Delhi atmospheric emission quantification, assessment and impacts (DelhiFlux)

UK - Department for Business, Energy and Industrial Strategy (BEIS)

Inventories of emissions of pollutants to air form the basis for model predictions of air quality, visibility, human exposure, human health impacts, and climate change. They are further required to understand relationships between individual source locations or source types and targets. None of the model predictions and analyses can be better than the emission database on which they are founded. This project seeks to greatly improve the emissions inventory for the wider Delhi area, one of the most polluted conurbations globally. The emission inventory will be compiled at a 1 km x 1 km resolution with diurnal and seasonal temporal profiles. It will cover NOx, SOx, NH3, total volatile compounds with breakdown into its chemical profile, particulate matter in fine (PM2.5) and coarse (PM10) size ranges, together with the toxic metal components within, as well as CO2 and CO as combustion tracers. To improve the emission inventory we will make laboratory-based measurements of emission factors and also measure, for the first time in India, the emissions from individual vehicles under real-world driving conditions to characterize the actual Delhi vehicle fleet. We will further perform the first micrometeorological flux measurements of these compounds above the city and study their enrichment along a transect. This will provide further information on potentially missing sources and serve as a direct assessment of the quality of the emissions inventory. We will further apply a state-of-the-art chemistry and transport model to infer the concentrations that would be expected on the basis of the new emissions inventory for comparison against concentration data from air quality networks and the wider NERC-MRC-MoES-DBT programme. ODA compliance: By providing the emissions data required to assess human exposure and develop cost-effective solutions to combat air pollution in Delhi, the project will target poverty and development issues. Accurate knowledge of emissions is a key factor underpinning the development of mitigation strategies which will deliver improved public health, whilst further allowing economic growth. Both the UK and Indian research teams will benefit from their interaction and exploitation of complementary expertise. The project will leave a legacy beyond the project lifetime by increasing the research capacity of the Indian teams and providing the knowledge base which will allow the findings to be extrapolated to the rest of India. Thus, the project findings will continue to contributing to the improvement of life and welfare of more than a billion people.

Project identifier:

GB-GOV-13-FUND--Newton-NE_P016502_2

Start Date:

2019-12-01

Activity Status:

Implementation

Total Budget:

£82,319.88


UK Aid Direct Fund - working with small and medium charities

UK - Foreign, Commonwealth and Development Office

To provide competitive funding to UK and overseas-based small and medium-sized civil society organisations , to support them in contributing to the decline of poverty in a range of the poorest countries, working towards the achievement of the Millennium Development Goals (MDGs) and the post-2015 Sustainable Development Goals (SDGs).

Project identifier:

GB-1-202035

Start Date:

2010-09-06

Activity Status:

Implementation

Total Budget:

£320,539,619


Global Antimicrobial Resistance Innovation Fund (GAMRIF) – UK-Argentina: tools to tackle AMR in the Environment

UK - Department of Health (DH)

This is a bilateral partnership with Argentina to support research to tackle antimicrobial resistance (AMR) in agriculture and the impact on the environment. Successful projects are a partnership of UK companies and research orgnisations, with Argentinian companies and research organisations. The competition and partnership will be delivered in the UK by the Biotechnology and Biological Sciences Research Council (BBSRC) in partnership with the Natural Environment Research Council (NERC), both part of UK Research and Innovation (UKRI), and delivered and matched-funded, on a resource basis, by the National Scientific and Technical Research Council (CONICET) in Argentina.

Project identifier:

GB-GOV-10-GAMRIF-WP4-UK-Argentina

Start Date:

2018-04-01

Activity Status:

Implementation

Total Budget:

£4,999,999




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