Go to main content

FCDO ODA allocations for 2021/22 were announced on 21 April 2021. Changes to individual programmes are underway. The information on this website may not reflect the latest allocated budgets for this year. This information will be updated in due course.

UK aid from the British people
  1. Home
  2. Search Results

Search Results for: "Kings College London"

Sort results by: Title
Default filter shows currently active projects. To see projects at other stages, use the status filters.
Now showing projects 1 of 1

Molecular Genetics of Lobular Breast Cancer in a South African cohort and effect of HIV infection.

UK - Department for Business, Energy and Industrial Strategy

Invasive lobular breast cancer (ILC) has distinct etiological, clinical and biological characteristics compared with the more common invasive ductal/no special type carcinoma (IDC). ILCs are characterized by E-cadherin loss, show stronger associations with the use of hormone replacement therapy (HRT) than IDC and have a different pattern of metastatic spread to IDCs, tending to infiltrate the peritoneum, ovary and gastrointestinal system. There is some evidence that they are less chemo-sensitive than IDC and that the 10-year survival rate of women with ILC is lower than that of ER+ IDCs. ILC accounts for 10-15% of all invasive breast cancer in Western countries and is less frequent in lower and middle income countries presumably due to lifestyle factors and lack of HRT use. However, there is evidence from the USA that African Americans have more aggressive invasive lobular carcinoma subtypes and inferior early outcomes. It is also likely that with changes in reproductive behaviors and westernized lifestyle factors there will be an increase in lobular breast cancer in sub-Saharan Africa. The objectives of this study are to: 1. Characterize clinico-pathological features and molecular genetics of ILC in African women to assess whether they have a more aggressive phenotype than a UK cohort of ILC 2. Assess whether HIV infection has any impact on the above and if anti-retrovirals can affect the metabolism of tamoxifen, a drug frequently used in the treatment of ILC. 3. Assess whether circulating tumor DNA can be used to detect metastatic ILC in HIV- and HIV + patients. 4. Develop a collaboration between the teams at Kings College London and University of Witwatersrand so that the above can be expanded to other subtypes of breast cancer

Project Identifier:
GB-GOV-13-FUND--GCRF-MR_S014268_1
Activity Status:
Implementation
Start Date:
15-11-2018
Total Budget:
£202,436


Results Filter

Status

Activity Status

Locations

+

Countries

+

Regions

Sectors

Sectors
+

Organisations

Implementing Organisations

Implementing Organisations

Start and end date

This site uses cookies

We use Google Analytics to measure how you use the website so we can improve it based on user needs. Google Analytics sets cookies that store anonymised information about how you got to the site, the internal pages you visit, how long you spend on each page and what you click on while you're visiting the site. Read more