Multi-Stage Malaria Vaccine Consortium (MMVC)
Project disclaimer
Description
With exciting progress being made in vaccine development at all stages of the life cycle – pre-liver, liver, red blood cell and bloodstream stages – MMVC has ambitious plans to combine them in a single formulation, maximising the benefits of the individual vaccines. The four-stage vaccine will include a next-generation version of RTS,S, known as R21, a liver-stage vaccine that has shown positive results in EDCTP-funded trials, a promising vaccine targeting a key protein involved in red blood cell invasion, PfRH5, and a vaccine targeting a key protein in the final bloodstream form, Pfs25. Results from a series of controlled human infection studies – using new capacity in Africa – and pilot trials will inform the design of an appropriate vaccination strategy. This will be tested in a phase II trial in infants in sites of different levels of malaria transmission. The project will also build capacity to test the vaccine in adults as a possible way of blocking transmission to mosquitoes in malaria elimination campaigns.
Objectives
Research and development activity contributing to the UK’s strategy to address key development challenges.
Location
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Status Implementation
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Programme Spend
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Participating Organisation(s)
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Sectors
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Budget
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Download IATI Data for GB-GOV-13-OODA-MRC-MK6NR8M-DDDLFJT-26SHHZG