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Fleming Fund - Independent Evaluation
UK - Department of Health and Social Care (DHSC)
The independent evaluation will assess how far the outputs of the portfolio of Fleming Fund country and regional grants, and the Fleming Fellowships contribute to the outcomes and impact identified by the Department of Health and Social Care (DHSC). Six specific evaluation questions were agreed during the inception phase for the evaluation. In answering these six questions, the evaluation intends to meet two objectives: 1. In 2019, the evaluation will generate learning to inform course correction and adaptation in the present phase of support; 2. In late 2020, the evaluation’s focus will shift to providing an independent summative judgement of the Fund’s results and achievements. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Country and Regional Grants and Fellowships Programme
UK - Department of Health and Social Care (DHSC)
The Fleming Fund helps low- and middle-income countries to fight antimicrobial resistance. A management agent has been appointed to deliver: country grants 24 low- and middle-income countries, regional grants in West Africa, East and Southern Africa, South Asia and South East Asia, and a global fellowships programme. These initiatives aim to improve laboratory capacity and diagnosis as well as data and surveillance of antimicrobial resistance (AMR). Through the country and regional grants and the fellowships programme the Fleming Fund will: build laboratory capacity for diagnosis; collect data on drug resistance, drug quality, drug use and the burden of disease associated with AMR; enable the sharing of data relevant to AMR locally, regionally, and internationally; encourage the application of data to promote the rational use of antimicrobials; shape a sustainable system for AMR surveillance and data sharing; and increase national leadership in addressing AMR. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund
UK - Department of Health and Social Care (DHSC)
The Fleming Fund is a £265m commitment by the UK Government to support low- and middle-income countries to tackle antimicrobial resistance (AMR) through improving surveillance capacity. Information about individual Fleming Fund projects and contracts can be found under the "child activities" linked to this activity. The Fleming Fund aims to: 1. support the development of National Action Plans for AMR; 2. develop and support the implementation of protocols and guidance for AMR surveillance and antimicrobial use; 3. build sustainable laboratory capacity for AMR sensitivity testing and diagnosis; 4. build sustainable drug resistance surveillance capacity and networks; 5. enable the sharing of drug resistance data locally, regionally and nationally; 6. facilitate the increased use of drug resistance data to monitor and address resistance as it evolves; and 7. advocate for the application of data to promote the rationale use of antimicrobials for human health, animal health and agriculture. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
World Health Organization (WHO) UK annual assessed contribution
UK - Department of Health and Social Care (DHSC)
The UK Department of Health and Social Care (DHSC) annual assessed contribution to the World Health Organization (WHO).
Fleming Fund - Multi Party Trust Fund for Antimicrobial Resistance (AMR MPTF)
UK - Department of Health and Social Care (DHSC)
Contribution to the United Nations Multi Party Trust Fund (MPTF) for AMR - the joint funding mechanism for FAO, OIE and WHO Tripartite over an initial five-year period (2019-2024). The MPTF seeks to promote increased integration and coordination within the tripartite and promote One Health action to tackle AMR.
Fleming Fund - Contribution to the International Reference Centre for Antimicrobial Resistance
UK - Department of Health and Social Care (DHSC)
The Fleming Fund contribution to a UK draw-down service for technical assistance, training and quality assurance for low and middle income countries to support antimicrobial resistance (AMR) surveillance system building across all one-health sectors. The objectives of the reference centre are to: 1. Develop capacity of low- and middle-income countries (LMICs) for surveillance of AMR and antimicrobial use (AMU) through residential AMR training workshops, country visits to partners to offer training, provision of proficiency testing schemes; 2. Strengthen governance related to AMU and AMR by providing expert advice on new or emerging resistances that present a threat to animal or public health, providing expert advice on how to bench-mark capability and the authorisation of antibiotics and providing verification testing at our UK laboratories; 3. Promote good agricultural practices and prudent use of antimicrobials by providing advice and support for the adaptation and implementation of alternatives to antibiotics; and 4. Raise awareness of AMR by publishing and contributing to expert reports and peer-reviewed scientific manuscripts. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater
Global Antimicrobial Resistance Innovation Fund (GAMRIF) - InnoVet AMR: Innovative Veterinary Solutions for AMR with IDRC
UK - Department of Health and Social Care (DHSC)
InnoVet-AMR is a partnership between DHSC and the International Development Research Centre (IDRC) aimed at reducing the emerging risk that antimicrobial resistance (AMR) in animals poses to global health and food security. InnoVet-AMR will fund research to develop new animal vaccines and other innovations to fight AMR in livestock (swine and poultry) and aquaculture production, particularly in low- and middle-income countries (LMICs). Through InnoVet-AMR, IDRC and DHSC aim to achieve two main objectives: (1) support research that will identify innovative veterinary solutions, including vaccines and alternative solutions, to reduce the use of antimicrobials in livestock and aquaculture operations in LMICs; (2) build effective partnerships to better coordinate discovery, development and sustainable delivery of affordable innovative veterinary solutions to reduce the use of antimicrobials in livestock and aquaculture operations in LMICs. Projects funded through the Global AMR Innovation Fund (GAMRIF) will primarily benefit people in LMICs, where the burden of drug-resistant infection is greater.
Global Antimicrobial Resistance Innovation Fund (GAMRIF) - UK-Argentina: tools to tackle AMR in the Environment
UK - Department of Health and Social Care (DHSC)
This is a bilateral partnership with Argentina to support research to tackle antimicrobial resistance (AMR) in agriculture and the impact on the environment. Successful projects are a partnership of UK companies and research orgnisations, with Argentinian companies and research organisations. The competition and partnership will be delivered in the UK by the Biotechnology and Biological Sciences Research Council (BBSRC) in partnership with the Natural Environment Research Council (NERC), both part of UK Research and Innovation (UKRI), and delivered and matched-funded, on a resource basis, by the National Scientific and Technical Research Council (CONICET) in Argentina. The aim of this partnership is to generate new knowledge and provide a deeper evidence base that can help to reduce the impact of drivers of AMR in the environment from agricultural sources as they apply to Argentina and low- and middle- income countries (LMICs). This includes research towards the development of theroretical frameworks for surveillance and reporting on AMR and antibiotics, and research towards the development of strategies for manure, slurry and waste management. Projects are also required to produce outputs that translate research into policy, such as policy briefings or best practice position papers for LMICs. Projects funded through the Global AMR Innovation Fund (GAMRIF) will primarily benefit people in LMICs, where the burden of drug-resistant infection is greater.
Global Antimicrobial Resistance Innovation Fund (GAMRIF) - Accelerating Antibacterial Innovation with CARB-X
UK - Department of Health and Social Care (DHSC)
Through the Global AMR Innovation Fund (GAMRIF), the UK Department of Health and Social Care (DHSC) has invested £20 million over three years in Boston University’s Combating Antibiotic Resistant Bacteria Accelerator (CARB-X), which is a non-profit, multi-donor international partnership that supports innovative early product research and development focused on the most dangerous drug-resistant bacteria. This contribution will invest in high-value, innovative research to accelerate the development of products to reduce the harm from drug-resistant infections. The aim of this project is to invest in high-value, innovative research to accelerate the development of products up to and including Phase I to reduce the harm to human health, welfare and economic growth from drug-resistant infections. In particular, the programme will focus on prevention (including vaccines) and alternatives to antibiotics for humans as primarily and directly relevant to people in low- and middle-income countries (LMICs). Projects funded through GAMRIF will primarily benefit people in LMICs, where the burden of drug-resistant infection is greater.
Global Antimicrobial Resistance Innovation Fund (GAMRIF)
UK - Department of Health and Social Care (DHSC)
Global Antimicrobial Resistance (AMR) Innovation Fund Programme
Fleming Fund - GRAM Global Burden of Disease Project
UK - Department of Health and Social Care (DHSC)
Grant to University of Oxford/Institute of Health Metrics and Evaluation to collect, synthesise and visualise data on the burden of disease associated with anitmicrobial resistance (AMR), quantify the problem and promote policy attention and resource allocation to tackle the issue. To collect data on the burden of disease associated with antimicrobial resistance (AMR) in low- and middle-income countries (LMICs), synthesise this data, and ensure that AMR is included within the Global Burden of Disease study. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Contribution to the International Reference Centre for Antimicrobial Resistance
UK - Department of Health and Social Care (DHSC)
The Fleming Fund contribution to a UK draw-down service for technical assistance, training and quality assurance for low and middle income countries to support antimicrobial resistance (AMR) surveillance system building across all one-health sectors. The objectives of the reference centre are to: 1. Develop capacity of low- and middle-income countries (LMICs) for surveillance of AMR and antimicrobial use (AMU) through residential AMR training workshops, country visits to partners to offer training, provision of proficiency testing schemes; 2. Strengthen governance related to AMU and AMR by providing expert advice on new or emerging resistances that present a threat to animal or public health, providing expert advice on how to bench-mark capability and the authorisation of antibiotics and providing verification testing at our UK laboratories; 3. Promote good agricultural practices and prudent use of antimicrobials by providing advice and support for the adaptation and implementation of alternatives to antibiotics; and 4. Raise awareness of AMR by publishing and contributing to expert reports and peer-reviewed scientific manuscripts. Projects funded through the Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater
Global Antimicrobial Resistance Innovation Fund (GAMRIF) - Innovation in AMR Diagnostic Tools with FIND
UK - Department of Health and Social Care (DHSC)
FIND is a global non-profit product development partnership that aims to develop, evaluate and deliver high-quality affordable diagnostic tests for poverty-related diseases. UK Department of Health and Social Care (DHSC) funding through the Global AMR Innovation Fund (GAMRIF) will support FIND’s work to enhance the impact of diagnostic tools for antimicrobial resistance (AMR), to support improved AMR surveillance and antibiotic stewardship. This work has two areas of focus: 1) to develop technological methods to connect data from patient testing and health provider consultations to larger data systems, such as national and international AMR surveillance programmes. This will lead to improved antibiotic use and AMR surveillance through increased access of data; and 2) to develop a new diagnostic technologies for drug-resistant gonorrhea, which will enable improved diagnosis and therefore use of new antibiotics. Projects funded through GAMRIF will primarily benefit people in low- and middle-income countries, where the burden of drug-resistant infection is greater.
Global Antimicrobial Resistance Innovation Fund (GAMRIF) - Vaccine Innovation with BactiVac
UK - Department of Health and Social Care (DHSC)
Vaccine Innovation with BactiVac is a partnership between the UK government and the Bacterial Vaccinology Network (BactiVac) to support the development of vaccines for AMR in humans and animals. The UK government has invested up to £1 million over one year into BactiVac, which is one of 5 networks that are supported by the Global Challenges Research Fund (GCRF) Networks in Vaccines Research & Development. This is co-funded by the Medical Research Council (MRC) and Biotechnology and Biological Sciences Research Council (BBSRC). The primary aim of this investment is to support new, diverse research projects to gain preliminary data and encourage establishment of new research partnerships, and allow these collaborations to build a track record, which will allow them to attain further funding. It is expected that some of these projects will fail, yet the dissemination of both positive and negative research outcomes is valuable and expected. Funded projects will undertake early stage research and development with catalyst pump-priming funding around the world to help drive the development and uptake of vaccines for antimicrobial resistance (AMR) for the benefit of people in low- and middle-income countries (LMICs). Projects funded through the Global AMR Innovation Fund (GAMRIF) will primarily benefit people in LMICs, where the burden of drug-resistant infection is greater.
Fleming Fund - Multilateral Grant to Food and Agriculture Organisation (FAO)
UK - Department of Health and Social Care (DHSC)
Contribution to the Food and Agriculture Organisation (FAO) to increase public and political awareness of antimicrobial resistance (AMR) and support countries with AMR National Action Plans. The objectives of the Fleming Fund grant with FAO are to: 1. support development and implementation of AMR National Action Plans in 12 low- and middle-income countries (LMICs) in sub-Saharan Africa and South and South-east Asia; 2. strengthen regulatory frameworks; 3. increase societal awareness and understanding of AMR; 4. develop good practices in food and agriculture sectors, and ensure these are able to be implemented in target countries; and 5. strengthen the coordination across WHO, FAO and OIE in supporting the One Health agenda globally, and more specifically in LMICs. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Multilateral Grant to World Health Organization (WHO)
UK - Department of Health and Social Care (DHSC)
Contribution to the World Health Organization (WHO) to support countries with antimicrobial resistance (AMR) National Action Plans and development of global protocols for collection of AMR data. The objectives of the Fleming Fund grant with WHO are to: 1. support countries to develop National Action Plans aligned with our regional focus in Sub-Saharan Africa, South and South-East Asia; 2. develop a One Health surveillance protocol on antimicrobial resistance focused on Escherichia coli (E. coli); 3. develop, pilot and roll out methods for antibiotic consumption and use monitoring; 4. Develop and support countries to implement of a new classification of antibiotics within the Essential Medicines List (EML) and the AWaRe categorisation to encourage rational use of antibiotics; 5. to support a deeper understanding of SF antimicrobials and their impact upon AMR; and 6. strengthen the coordination across WHO, FAO and OIE in supporting the One Health agenda globally, and more specifically in low- and middle-income countries (LMICs) Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
UK Public Health Rapid Support Team - Rapid investigation and response
UK - Department of Health and Social Care (DHSC)
"Created in 2016, the UK-PHRST is the primary arm of Her Majesty’s Government to provide and coordinate the UK’s public health response to outbreaks in LMICs. The UK-PHRST is a unique collaboration between Public Health England and the London School of Hygiene and Tropical Medicine with input from a number of academic partners. The UK-PHRST’s remit covers outbreak response, research, and capacity building, as components of its integrated triple mandate: • Rapidly investigate and respond to disease outbreaks at their source in LMICs eligible for UK Official Development Assistance (ODA), with the aim of stopping a public health threat from becoming a broader health emergency • Conduct research to generate an evidence base for best practice in epidemic preparedness and response • Build capacity for improved and rapid national response to disease outbreaks in LMICs and contribute to supporting implementation of IHR at the request of national governments or international stakeholders such as WHO. The UK-PHRST rapidly deploys a standing team of multidisciplinary public health professionals and researchers as required in countries that are a priority for the UK’s ODA programme. The UK-PHRST full-time Core Deployable Team consists of specialists in epidemiology, laboratory microbiology, infection prevention and control, clinical case management and clinical research, social science, data management and logistical support who are available to deploy within 48 of an approved request. Reservists and Field Epidemiology Training Programme (FETP) Fellows complement this team, providing surge capacity and specialist expertise when needed. The UK-PHRST is financed through UK Official Development Assistance (ODA) funding through the Department of Health and Social Care. The UK-PHRST Director is the accountable person to the UK Government, through PHE, for delivery of the UK-PHRST objectives." "The UK-Public Health Rapid Support Team is a key international partner in epidemic disease response. We partner with low- and-middle income countries to respond to infectious disease outbreaks before they can develop into global health emergencies. We work closely with international organisations, partner country governments and non-governmental organisations to: - Rapidly investigate and respond to disease outbreaks at their source in LMICs eligible for UK Official Development Assistance, with the aim of stopping a public health threat from becoming a broader health emergency - Conduct research to generate an evidence base for best practice in epidemic preparedness and response - Strengthen capacity for improved national response to disease outbreaks in LMICs We are an innovative partnership between the UK Health Security Agency and the London School of Hygiene & Tropical Medicine, funded with UK aid by the UK Department of Health and Social Care." The UK Public Health Rapid Support Team (UK -PHRST) has the following main objectives: 1) Within ODA eligible countries to support the rapid investigation and response to disease outbreaks at source, with the aim of stopping a public health threat becoming a health emergency. 2) Conduct rigorous research to aid epidemic preparedness and response and improve future response. 3) Generate an evidence base for best practice in disease outbreak interventions within ODA eligible countries. 4) Train a cadre of public health reservists for the UK -PHRST who can be rapidly deployed to respond to disease outbreaks. 5) Build capacity in-country for an improved and rapid national response to disease outbreaks and contribute to supporting implementation of the International Health Regulations (IHR).
International Health Regulations (IHR) Strengthening project
UK - Department of Health and Social Care (DHSC)
The DHSC ODA-funded International Health Regulations Strengthening Project (IHR-S) provides peer to peer technical expertise through the UK Health Security Agency (UKHSA) to support public health partners to prepare, prevent, detect and respond to global health threats and increase compliance with the WHO International Health Regulations (IHR 2005). Compliance with IHR (2005) is fundamental as infectious disease outbreaks are expected to become more frequent in the future and preparedness is necessary to reduce health threats both internationally and within the UK. Lack of compliance to meet IHR (2005) requirements places countries under greater risk from disease outbreaks and other health emergencies, and has potentially wider implications on a global scale, as evidenced by the spread of Covid-19. IHR (2005) includes 13 technical areas such as surveillance, laboratories and points of entry as focal points to support countries to prevent, detect and respond to health threats. The IHR Strengthening Project has three key aims: to build technical capability, to strengthen leadership, systems and workforces, as well as to develop sustainable public health systems. IHR-S works bilaterally with four priority partner countries and three regions [including Nigeria, Pakistan, Ethiopia, Zambia, Africa (primarily through Africa CDC), the Eastern Mediterranean and Indo Pacific regions]. Over the course of this project the UK will work closely with the World Health Organization (WHO) to help it fulfil its leadership role in implementing the IHR and in responding to global public health emergencies. The project will work intimately with national governments, development partners and with regional and sub-regional agencies to deliver its support. This support will be coordinated with support from other donors, ensuring it adds value and is sustainable, identifies and responds to gaps, complements support from others and aligns behind nationally identified priorities. Implementation of UK support will be led by Public Health England, but may include contracting and working through UN agencies where appropriate and where this will maximise value for money.
Fleming Fund - Multilateral Grant to World Organisation for Animal Health (WOAH)
UK - Department of Health and Social Care (DHSC)
Contributions to the World Organisation for Animal Health (WOAH ) to improve regulatory frameworks and monitor targeting veterinary medicines. The objectives of the Fleming Fund grant with WOAH are to: 1. improve recognition of the critical importance of tacking antimicrobial resistance (AMR) and raised awareness among veterinary health professionals and the general public; 2. agree WOAH standards on AMR and progress towards implementation of these standards in low- and middle-income countries (LMICs); 3. support member states to collect and report data on the use of antimicrobial agents in animals; 4. improve regulatory frameworks targeting veterinary medicines including antimicrobials; and 5. strengthen the coordination across WHO, FAO and WOAH in supporting the One Health agenda globally, and more specifically in LMICs. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
Fleming Fund - Civil society engagement through South Centre grant
UK - Department of Health and Social Care (DHSC)
Through a grant to the South Centre the Fleming Fund is seeking to increase understanding of the challenges around antimicrobial resistance (AMR) and advocate for action among governments, civil society organisations and networks in low- and middle-income countries (LMICs). The grant to the South Centre will aim to 1. support positive developments in global processes of AMR and commitments to actions on addressing AMR; 2. assist developing countries to participate positively in the global processes on AMR and to have a sense of ownership of this agenda; 3. build the knowledge base and capacity of LMICs to understand the nature and seriousness of the AMR crisis and to take policy measures and actions nationally to address this crisis; and 4. strengthen the capability of civil society groups to build awareness and take actions on AMR issues. Projects funded through Fleming Fund will benefit people in low- and middle-income countries, where the burden of drug resistant infection is greater.
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