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Department of Science, Innovation and Technology
Climate Science for Service Partnership (CSSP) Brazil - Calls- tender-UNIVERSITY OF LEEDS
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
Collaborative climate science research programme between Brazil and UK to improve understanding of recent climate changes and Brazil’s role in mitigation activities to inform international negotiations; to enhance projections of future weather and climate extremes and impacts to inform decision making and contribute to disaster risk reduction in Brazil. Research hydrological cycle responses to land-use change and climate change over Brazil
Weather and Climate Science for Service Partnership S E Asia (WCSSP) - Calls - tender - UNIVERSITY OF LEEDS
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
Strengthened partnership between meteorological services in UK, Philippines, Malaysia Vietnam, and Indonesia - research on understanding and evaluating convective processes over SE Asia.
Climate Science for Service Partnership (CSSP) Brazil - Calls- tender-UNIVERSITY OF LEEDS
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
Collaborative climate science research programme between Brazilian and UK to improve understanding of recent climate changes and Brazil’s role in mitigation activities to inform international negotiations; to enhance projections of future weather and climate extremes and impacts to inform decision making and contribute to disaster risk reduction in Brazil. Research on Moisture Transport and Deforestation.
Implementation and impact of the ban on the sale of ultra-processed foods to minors in Mexico
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC AGHRB Award tO investiage implementation and evaluation on the impact of the ban on the sale of ultra-processed foods to minors in Mexico
Removing the marketing power of cigarettes: A multi-method study aimed at protecting the health of adolescents in Latin America
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC AGHRB Award: A multi-method study aimed at protecting the health of adolescents by removing marketing powers of cigarettes in Latin America
Expanding syphilis screening among pregnant women in Indonesia using the rapid dual test for syphilis & HIV with capacity building: The DUALIS Study
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
Mother-to-child transmission (MTCT) of syphilis, or congenital syphilis, is the second leading cause of preventable stillbirth globally, preceded only by malaria. While significant progress has been made over the past decade in preventing MTCT of HIV, the same cannot be said for syphilis. In 2016, there were more than half a million (about 661,000) cases of congenital syphilis, resulting in over 200,000 stillbirths and neonatal deaths. It is crucial that all women are provided with early syphilis screening and treatment as part of high-quality antenatal care (ANC). Transmission of HIV and syphilis to newborns is essentially preventable through the use of affordable and reliable rapid tests to support early diagnosis and treatment in pregnancy. A single rapid test for syphilis was added to Indonesia's MTCT HIV programme in 2013. While the level of HIV testing in pregnancy has been gradually rising since that time from 2% to 27%, testing for syphilis has barely shifted from 0.45% to 0.9%. Based on an estimated syphilis prevalence rate of 1.2%, it is predicted that 10,169 stillbirth cases could potentially be averted by increasing the coverage of antenatal syphilis screening in Indonesia. The dual test for HIV/syphilis point-of-care testing for pregnant women has been shown to be an effective and cost-saving tool for accelerating syphilis testing uptake in several low- and middle-income countries. It was approved for use in Indonesia in 2019 but is yet to be implemented. This is in part due to the low political priority given to syphilis compared with HIV, low levels of investment by the government and donors, and a paucity of evidence on the effectiveness and cost-effectiveness of the dual test in routine care in Indonesia. For this study, we have partnered with the Indonesian Ministry of Health, WHO Indonesia, and a community NGO to evaluate the impact of the dual test with supporting elements (including capacity building the areas of screening procedures, inventory management, staff and patient engagement, data management and referrals, standard operating procedures, procurement and supply) in 4 districts of Indonesia. This cluster-randomised trial will be the first in Southeast Asia to assess the effectiveness, acceptability, cost-effectiveness, and affordability of the dual test for HIV and syphilis in routine ANC services. This intervention has the potential to contribute significantly to improved maternal and child health in Indonesia while building health system capacity to strengthen the prevention, detection, and treatment of syphilis.
Integrating and scaling seasonal climate-driven dengue forecasting
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
Outbreaks of climate sensitive diseases present a major growing threat to human health, but they are predictable and maybe even preventable. The mosquito transmitted disease dengue is one of the fastest growing global infectious diseases and now causes over 400 million annual cases globally. Dengue is becoming the primary acute infectious disease threat in countries such as Vietnam and Malaysia. Between 2017 and 2019, Vietnam averaged over 200,000 cases every year and in Malaysia dengue fever has the highest incidence rate among any other communicable disease (398 cases per 100,000). Dengue outbreaks are preventable with existing interventions, but only if they are used in the right places at the right times. The ability to forecast disease outbreaks months in advance can reduce the burden on health services. This is important in resource-constrained Low and Middle Income Countries (LMICs) where they can make the difference between an effective and efficient proactive response compared to a costly and often unsuccessful reactive response. We aim to demonstrate the value of disease forecasting via a local level dengue forecasting system in Vietnam and Malaysia, which will pave the way for scale up of dengue forecasting and other digital health solutions for climate sensitive diseases. We have developed the necessary disease forecasting techniques as part of the Dengue forecasting MOdel Satellite-based System (D-MOSS) project. Although this system has been operational since July 2019 in Vietnam and July 2020 in Malaysia, more work is needed to bridge the implementation gap to ensure forecasts have direct actionable and measurable impacts on preventing outbreaks at a local level. Further research is required to establish if the forecasting techniques already in operation are capable of producing accurate forecasts at the required spatial and temporal resolutions, tailored to the practices applied by specific sectors of the health system. We will test this by co-developing new forecasts that provide advance predictions in Vietnam and Malaysia. Through a series of longitudinal workshops we will develop risk assessment protocols that link forecasts to outbreak prevention activities at different sectors of the Vietnamese and Malaysian health systems. These knowledge gaps will be addressed by a multidisciplinary team of dengue experts, modellers, public health experts, software engineers and early warning systems experts from multiple institutes in Vietnam, Malaysia and the UK. Training and co-design of the research is central to all aspects of our proposal and we intend to leverage the equitable partnerships established as part of the D-MOSS project to meet our aims. Cross-cutting activities will compare and contrast the operational context in these countries and enable collaboration between them with the goal of deriving generalisable principles and specific guidelines for expansion to other countries. This research will demonstrate clear health value against dengue and other Aedes mosquito-borne diseases (e.g. chikungunya, Zika) in Vietnam and Malaysia, and a plan for how the intervention will be scaled up to other LMICs currently struggling to address the growing threat of dengue and other climate-sensitive diseases. In the longer term, this project will provide evidence on the value of forecasting to health systems for a wide range of health conditions.
Developing an mHealth intervention to strengthen the community mental health system in the context of the COVID-19 pandemic in Peru
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC JHSRI award to develop an mHealth intervention to strengthen the community mental health system in the context of the COVID-19 pandemic in Peru COVID-19
Balancing safety and good care in the context of infectious disease outbreaks: learning health systems for infection prevention and control in Uganda
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC JHSRI award to balance safety and good care in the context of infectious disease outbreaks: learning health systems for infection prevention and control in Uganda COVID-19
Learning health systems: fostering participatory learning and action to equip rural health workers as change agents for maternal and newborn care.
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC JHSRI l aim is to understand if and how a participatory learning and action (PLA) intervention can improve organisational learning culture amongst rural health workers (HWs) and experiences of person-centred maternal and newborn health (MNH) care amongst women in rural South Africa.
Regulating e-pharmacy: challenges and opportunities for access and quality of care in LMIC health systems
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC JHSRI to assess the performance of e-pharmacies in India and Kenya, analyse the systems that regulate them, and identify opportunities for improving medicine quality, safety and accessibility.
Developing Strategies to coordinate HEalthcare provision b
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC JHSRI award to design a health system-wide strategy to adapt healthcare provision to population mobility between The Gambia and Senegal.
Tackling antimicrobial resistance across dentistry in Sub-Saharan Africa.
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
What's the challenge? Tackling antimicrobial resistance (AMR) is crucial for global health and sustainable development. Low- and middle-income countries (LMICs), like Ghana and Uganda, are particularly affected. UK Government has pledged to play a leading role in improving health to deliver a safer and more prosperous world, including through an improved response to AMR. Globally, dental professionals are responsible for one-in-ten antibiotic prescriptions across human healthcare. In Sub-Saharan Africa (SSA), dental teams are among the highest prescribers of antibiotics, with some studies finding nine out of ten prescriptions outside of guidance. Dental teams in SSA have an essential role to play in keeping antibiotics working. What are the aims and objectives of our research? We aim to develop and test ways for dental teams to play their part in tackling AMR in SSA. Our first objective is to understand what influences unnecessary dental antibiotic use in Ghana and Uganda. Our second objective is to work with dental teams and patients as well as policy makers, healthcare service managers and the general public to develop an evidence-based way to reduce antibiotic prescribing by dental professionals. Our final objective is to prepare for an African-led clinical trial to test whether our proposed approach works. How are we approaching it? First, to understand what drives unnecessary antibiotic prescribing by dental professionals, we will ask a range of people and observe dental visits in hospitals and community healthcare settings in Ghana and Uganda. The observed dental teams and patients will be invited to interview to share their experience and insights about what influenced decision making during the visit. To gain wider perspectives on managing dental infections, policy makers, healthcare service managers and members of the public will be invited to take part in interviews and/or focus groups. Next, we will work with our stakeholders to develop evidence-based ways to reduce unnecessary antibiotic prescribing using information gathered in the first stage. Whilst we are not yet sure what these interventions will be, we think they might relate to hygiene and sterilisation procedures in dental clinics, prescribing guidelines, and education for dental teams. Finally, we will undertake eight in-depth case studies in urban and more rural areas of Ghana and Uganda to check whether the intervention is acceptable to dental teams and patients, and to prepare for a clinical trial by testing some of the details needed to make a trial practical. What will be the applications and benefits? The study results will form the basis of a grant application to conduct a clinical trial that evaluates the impact of the interventions on safely reducing antibiotic prescribing by dental professionals across SSA whilst still addressing patients' dental issues. The benefits of this research include expanding scientific knowledge about the factors influencing antibiotic prescribing by dental professionals in LMICs. Developing interventions to reduce antibiotic prescribing is just the first step; further testing will be needed. Ultimately, by reducing antibiotic prescribing in dentistry, this research will have a positive impact on global health and sustainable development by addressing AMR. Publicity To ensure visibility of the study and its findings, our research team members and collaborators will engage our stakeholders and audience through various channels, including their expert professional networks, social and other media, academic publications/conferences, and more novel ways using local traditional arts, story, illustrations and visual aids. Lay members from the UK, Ghana and Uganda will help create a plain English summary (and translation to local languages) for the public, and will ensure messaging promotes broader understanding and awareness of the important role of dental teams to keep antibiotics working.
GMP manufacture and Phase I clinical trial of a thermostable single-dose rabies vaccine for pre-exposure prophylaxis for children in endemic areas
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC BMC: DPFS Full July 2016 award - GMP manufacture and Phase I clinical trial of a thermostable singledose rabies vaccine for preexposure prophylaxis for children in endemic areas
Preemptive discovery of insecticide cross-resistance mechanisms for next generation malaria control products
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC IIB award to provide new understanding of the potential of different insecticides to be used together effectively to manage resistance, and provide diagnostics to screen wild mosquitoes for genetic changes resulting from control programmes
Dissecting the role of host receptor context and cytoskeletal disruption in malaria parasite invasion
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC IIB award to exploit generation of novel in vitro derived red blood cell phenotypes in order understand and dissect the dynamic remodelling of host RBC membrane and cytoskeletal proteins that occurs during malaria parasite invasion
Neurobiological pathways from trauma exposure to child mental health outcomes in a high adversity South African Birth Cohort
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC NMHB RM 19 Award looking at the neurobiological pathways from trauma exposure to child mental health outcomes in a high adversity South African Birth Cohort
Can malaria transmission be prevented through catastrophic failure of gametocyte quiescence?
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC Career development fellowship to study the unusual and poorly understood state of quiescence in mature infectious male and female Plasmodium gametocytes that are directly responsible for the transmission of the parasite from humans to mosquitoes.
A combination efficacy study in Africa of two DNA-MVA- or DNA- Env protein HIV-1 vaccine regimens with pre-exposure prophylaxis (PrEP)
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
MRC supplementary funding to support the extension of a European & Developing Countries Clinical Trial Partnership funded HIV efficacy vaccine trial
ODA Programmes within MRC Clinical Trials Unit
DEPARTMENT FOR SCIENCE, INNOVATION AND TECHNOLOGY
Clinical Trials Unit Southampton - International reputation for making important scientific discoveries in the lab and translating them into successful clinical treatments. Through links across the University, the NHS and industry able to push the boundaries of medical research and address key healthcare issues. There are a number of programmes under the CT unit: 1) The Blood borne viruses programme is currently focussed on two blood borne viruses with enormous global burden, and long term health and economic impact. DAC countries currently supported are Kenya, Uganda, South Africa, Zimbabwe, Vietnam, Thailand, Morocco, Mozambique, Egypt and Ukraine. The outcomes of these trials and studies will promote economic development and welfare by reducing the burden placed on these countries by these blood borne viruses 2) Respiratory infection: The DAC countries supported from the COVID-19 and TB trials being conducted in the respiratory programme are: Zimbabwe, Uganda, Mozambique, Ethiopia, South Africa, Zambia, India and Vietnam 3) The Syndromics programme has two sub-themes, the “acutely sick child in Africa” and “serious bacterial infections and antimicrobial resistance”, both of which are addressing development challenges by developing and testing interventions to reduce mortality and morbidity in children and adults in LMIC through programmes of randomised controlled trials, and associated epidemiological studies addressing questions around management and treatment. DAC countries currently supported are Kenya, Uganda, Mozambique, Ghana, Malawi, South Africa, Zambia, Bangladesh, Vietnam, Thailand, India, Brazil, China. The outcomes of these trials and studies will promote economic development and welfare by reducing the burden placed on these countries by acute and infectious diseases, particularly loss of economic output in adult carers due to illness in their children
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