Search Results for: "University of Birmingham"
1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMICs. 2) Create an environment where world-class global health research, focused on the needs of LMICs can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMICs. 4) Focus on priority areas which will have the greatest impact on health in LMICs in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice. 8) Retain a level of responsive research capacity to address emerging global health research requirements (Units only).
1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMIC. 2) Create an environment where world-class global health research, focused on the needs of LMIC can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMIC. 4) Focus on priority areas which will have the greatest impact on health in LMIC in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice.
The Darwin Initiative is a UK government grants scheme that helps to protect biodiversity and the natural environment through locally based projects worldwide. The initiative funds projects that help countries rich in biodiversity but poor in financial resources to meet their objectives under one or more of the biodiversity conventions. The objective is to to address threats to biodiversity such as: - habitat loss or degradation - climate change - invasive species - over-exploitation - pollution and eutrophication
Sightsavers’ research function focuses on funding research projects across all themes and technical expertise to research and evidence generation
ReCAP brings together current and formerly DFID funded research programmes in rural roads and transport services. The aim of the partnership is to improve accessibility of the rural poor in Africa and Asia to economic opportunities and social facilities through improvements to infrastructure and transport.
To increase the use of high quality evidence to inform policy and programmes in FCDO through the production of research and policy mapping analyses, evidence synthesis papers, systematic reviews and the funding of country specific research projects.
UK global leadership to synthesise evidence on the Best Buys and convene global decision makers to ensure evidence based policy making in education. This will support urgent reforms required in teaching at the right level, curricula and teacher reform to support learning across DFID countries. This programme responds to the manifesto commitment on girls' education.
The objective of the programme is to improve effectiveness of HMG investments in fragile and conflict affected situations (FCAS), by providing real-time data, expertise and public good research to inform DFID and Whitehall policy and operations including through the Whitehall Conflict Security and Stability Fund (CSSF) and DFID programmes. The programme is broken into two separate contracts: Lot 1 (X-border conflict dynamics/response), and Lot 2 (Violent and peaceful behaviour). This contract is Lot 1 which is broken into the following two parts: Part A: X-border conflict "hubs" and x-border "spokes." Research will examine networks operating between major conflicts including Afghanistan, through Iran to the Middle East, through the Levant, North Africa and the Gulf to East Africa. Research will include techology based methods (e.g. satellite and aeiral imager, financial data, geo-tracking, communications and/or social media) complemented by quantitative and qualitative field work. Part B: Innovating conflict responses in an era of x-border conflict. Research will collect and collate empirical evidence on international conflict response systems, including multi-lateral and bilateral efforts focussed on peace support or stability and how they can innovate to meet the challenges of x-border conflict.
The overall aim of BactiVac is to establish a bacterial vaccinology network that brings key individuals and organisations together to facilitate end-to-end bacterial vaccine development for low and middle income countries (LMICs) from exploratory research, through clinical trials, to licensure and implementation. No bacterial vaccinology network of this nature presently exists. Therefore, BactiVac will fill a major gap in global vaccinology, providing balance to the current critical mass of vaccinologists converging on outbreak and viral pathogens through the 'UK Vaccines Network', and WHO 'Research and Development Blueprint' and 'Coalition for Epidemic Preparedness Innovations (CEPI)'. BactiVac will draw together entities from the academic, industry and stakeholder sectors from the UK/high income countries (HICs) and LMICs involved in human and animal vaccine R&D to foster partnership, disseminate relevant information and provide catalyst project support with the aim of accelerating LMIC bacterial vaccine development. A particular focus will be to address knowledge gaps in the area, such as identification of bacterial vaccine priorities for LMICs, and to support the transition of vaccines from preclinical to clinical trials, where so many currently flounder. Specific objectives: 1. To establish an open network that connects key individuals and organisations from academia, industry and LMICs to fulfil unmet needs for bacterial vaccines, providing opportunities for the dissemination of knowledge and ideas, fostering partnerships and progressing bacterial vaccine R&D. 2. To establish a framework to address major gaps in our knowledge of bacterial vaccinology, including the prioritisation of LMIC-focused bacterial diseases for vaccine development, and identifying Clinical Research Organisations (CRO), Contract Manufacturing Organisations (CMO) and manufacturing capacities and capabilities to support bacterial vaccine development. 3. To provide support for small-scale projects that will prime substantive funding applications, with an emphasis on those that directly impact bacterial vaccine progression, and involve partnership between network members, particularly members from LMICs and industry. 4. To establish BactiVac as the advocacy network for bacterial vaccinology that campaigns for the need for bacterial vaccines as a means of reducing the burden of endemic bacterial disease, combatting AMR and improving economic development in LMICs. 5. To support training opportunities and exchanges, prioritising those involving LMIC members and industrial partners, for the transfer of knowledge and skills in bacterial vaccinology. 6. To interface with other groups, including other vaccine networks generated from this call, the Developing Countries Manufacturing Network (DCVMN), Veterinary Vaccinology Network (VVN), stakeholder organisation such as WHO and GAVI and funders such as the Bill and Melinda Gates Foundation BMGF) to maximize the reach and use of resources to achieve the network's objectives.
Sightsavers’ Global Technical Leads for education provide technical support to education programmes and technical expertise in project design
Whilst China is a global leader in genome sequencing, lack of resourcing has seen the implementation of genomics in clinical infectious disease research and control lag behind other countries. Most acutely there is a lack of sufficient genomic analysis and bioinformatics skills within the health care setting in China, making adoption of genomics in infectious disease research and control extremely difficult to implement. If China is to combat the increasing morbidity and mortality associated with multi-drug resistant (MDR) bacterial infection in its poorest and weakest members of society, then addressing this shortcoming is of paramount importance. Here we propose the generation of a research network of leading Chinese hospitals, and world-renowned microbial genomics researchers in the United Kingdom to address this pressing issue. We will consolidate, and build new partnerships to facilitate vital research investigating the transmission dynamics of (MDR) pathogens in Chinese hospitals, create a nucleus of highly trained bioinformaticians in the clinical setting, and create real-time sequencing capacity in hospitals. This will ensure an impact on the understanding and management of MDR infections long beyond the three-year lifespan of the proposed project. The proposed project revolves around three primary objectives: 1) To create a pool of clinical infectious disease researchers with excellent skills in microbial genomic data analysis, bioinformatics, and microbial genomic project design 2) To investigate the effective routes of introgression and transmission of carbapenemase producing Enterobactericeae (CPE) in Chinese hospitals 3) To combine phenotypic antimicrobial susceptibility profiles with genomic data to ascertain genetic factors which influence variation in minimum inhibitory concentration (MIC) levels.
ASAP-Delhi will provide an authoritative assessment of the sources, formation, characteristics and burden of air pollutants in Delhi, and the influence of the surrounding NCR (National Capital Region) city clusters, with a particular focus upon particulate matter (PM2.5 and nanoparticle abundance) as the pollutants with the greatest impact upon human health. This project (ASAP-Delhi) addresses aspects of theme 1 (Sources & Emissions) and theme 2 (Pollutant Processes) of the overall programme on Atmospheric Pollution and Human Health in an Indian Megacity, and comprises both stand-alone science objectives, and inputs to the wider programme. The specific science objectives of ASAP-Delhi are to: 1) Characterise the abundance, chemical and physical properties of particulate matter (PM) in Delhi, and the surrounding NCR city clusters, with a focus on PM2.5 and particle number. 2) Produce source profiles including molecular markers for selected key particulate matter sources in Delhi, via targeted field observations, existing partner data and secondary data analyses. 3) Directly quantify the sources of PM (mass and number concentration) in Delhi and the surrounding national capital region city clusters using a suite of independent, established and novel receptor modelling methods. 4) Assess the impacts of the NCR City Cluster pollutant burden upon air pollution levels in Delhi (and vice-versa), via novel analyses of existing and new spatially-resolved observations. 5) Elucidate the formation mechanism(s) of particulate matter during severe pollution episodes in Delhi, by evaluation of a range of new and recently suggested hypotheses. In addition to these self-contained science objectives, which address key current research questions and stakeholder needs, ASAP-Delhi will produce observational datasets for use in other components of the overall programme, and exploit results from other projects: -ASAP-Delhi will exploit measurements made in DELHIFLUX (laboratory emissions signature characterisation; site provision); PROMOTE (online organic PM characterisation) and AIRQUALNET (PM spatial distribution). -Outputs from ASAP-Delhi will support DELHIFLUX (emissions); PROMOTE and CADTIME (pollutant characterisation and seasonal, spatial distribution; process understanding; NCR PM budgets and regional import/export; model development and validation; mitigation policy development and evaluation); AIRQUALNET (sensor validation; pollutant spatial distribution) and DAPHNE (health-related pollutant characterisation, notably nanoparticles). We will maximise the impact of our findings through collaborations with a range of stakeholders, from other researchers to policy makers, as outlined in the Pathway to Impact and overall Programme Integration Plan. Note on Proposal Updates ASAP-Delhi has been updated in response to the Integration Workshop held in mid-2016, and moderation panel feedback. Principal changes to the programme of work relate to (i) expanded use of state-of-the-science online PM methodologies (WP1a) and new offline PM analyses (brown carbon, WP2); (ii) modifications to sampling sites and scheduling to integrate with other projects; and (iii) specific actions on data quality / assurance measures (WP1c). Additional proposal changes provide expanded detail on areas highlighted at the Workshop discussion: Location and integration of the NCR sampling sites vs. those operated by the various pollution control boards (CPCB, DPCC, UPPCB, HPCB) and the SAFAR network, including a map, and refined project management to reflect the structure of the wider programme. The overall goal, specific science objectives, and core funding request (staffing) remain unchanged, in keeping with the panel feedback.
The 'Disability Under Siege' Network Plus has the following overarching aim: To provide the intellectual, financial and logistical resources required by local practitioners to deliver a transformational step change in education provision for children with disabilities in conflict affected states. In order to achieve this aim, the programme will set out to meet the following objectives: 1) Support interdisciplinary research to critically evaluate dominant discourses, and individual and community attitudes toward disability in contexts of conflict. 2) Facilitate the development of equitable co-produced, multidisciplinary research and the gathering of evidence to inform education provision for those with disabilities in the Middle East. 3) Strengthen local and international capacity for implementing research designed to address challenges for disability inclusion in education (addressing SDGs 4.2/5/6, 10.2, 10.3, 17.5/6/17). 4) Develop equitable and sustainable partnerships, South-South as well as South-North collaborations, and sustainable legacy activities and practices. By working towards these objectives, the project will make a contribution to a range of Sustainable Development Goals, and also deliver a measurable difference to disability education provision in Low and Middle Income Countries (LMICs).
The Digital Technology-based New Business Model for Inclusive Development project is a multi-institution project aiming to carry out world class research addressing the challenges of inclusive development. Responding to the United Nations' call for Sustainable Development Goals (SDGs), it aims to develop new knowledge and policies to harness digital technologies for inclusive development by developing a novel Inclusive Digital Model (IDMODEL) that will enable and empower deprived youth and women to enhance their capabilities and improve their living standards. In particular, it will: 1) Develop, test and confirm a digital technology-based new business model that will enable the poor people to start a business based on their own skills and experiences while requiring minimum initial capital investment. 2) Evaluate the impact of this DT-based business model on jobs, income creation and capabilities building. 3) Analyse the underlying regulatory and capability conditions that are needed to ensure its success and scale up, and possibility to replicate this model in other developing countries. 4) Examine how the state, Multinational Enterprises (MNEs) and civil society can collaborate in implementing this model for inclusive development. It will achieve these objectives through 3 work packages (WPs) that create the structure of the project. -WP1: Developing a new business model to include the poor people into value creation activities empowered by existing and emerging digital technology. -WP2: Evaluating the impact of this new model on inclusive development envisioned by the United Nations and understanding the effects of underlying conditions in shaping the strength of such developmental impact. -WP3: Investigating how should the MNEs collaborate with local political and social actors to create value for inclusive development. These three WPs are designed to work as building blocks towards the completion of this project.
Humanitarian policy and practice is driven by the 'now' of crisis and urgency. But in contexts of protracted conflict and displacement, it is often the hidden damage that takes place over time that sets the terms for future violence, change, and possible peace. Rights for Time/Time for Rights Network Plus (R4T+) creates and justifies a new understanding of how time conditions war, displacement, and violence, and aims to shift the possibilities and frame of action for humanitarian protection and human rights. Drawing together in-country partners and academic experts from the arts and humanities, psychology, medical anthropology, refugee studies, gender studies, human rights, transitional justice, humanitarian law, and protection policy, we will develop interdisciplinary, peer-peer, case-based research bringing a temporal perspective to protection challenges. The R4T+ research objectives are: 1. Convene and develop a sustainable research network that will become a major transnational hub for developing new knowledges and practices for transforming the understanding of past, present, and future times of human rights; 2. Create new evidence bases to demonstrate the impact of the long-times of violence and trauma. Frequently hidden and, urgently, intersectional histories, pose unique and complex challenges to protection. New methodologies and measures are required to make hidden damage visible to law and policy; 3. Develop policy, practice, and legal thinking that can address the different times of violence. The fluctuating and impatient times of humanitarian law, policy, and practice are often at odds with the long times of violence. Precedent, habit, and protracted presentism all currently inhibit new and effective responses to risk, prediction, prevention, legislation, and protection. This objective aims to link new evidence bases, measures and methodologies with policy on a local, national, and international level; 4. Develop in-community arts, practices, and languages that can make the times violence culturally visible and operative. Our objective here is to actively support ownership of trauma, memory, and hope, and to provide new creative tools for advocacy and enduring change on the ground and in policy at local, national, and international levels.
Understanding, Developing, and Supporting Meaningful Work for Youth with Disabilities in Bhutan: Networks, Communities, and TransitionsUK - Department for Business, Energy and Industrial Strategy
AIMS The core aims of this research are to better understand... 1. The challenging and enabling factors that impact access to SCICS (Skills, reliable social Contacts, Information about the economic market, Capital, and Self-esteem/efficacy) and school transition, to promote positive social and economic outcomes for youth with disabilities in Bhutan. 2. The experiences, attitudes, and preparedness of youth with disabilities in Bhutan, as well as employers, in terms of education, inclusive employment, and transition from school to post-school. 3. The ways that skill and employment interventions - employment assessment toolkit, work skills and entrepreneurial workshops, dedicated coordinators, and microfinance - for youth with disabilities can be made more effective considering local social, cultural, and political contexts both in Bhutan, and in application to other global contexts. 4.How the ideals and principles of inclusive training and skills development, person-centred planning, and service practices can potentially contribute in the realisation of inclusive employment, and Bhutan's aspiration of achieving GNH, through strategic interventions and inter-governmental cooperation for meaningful employment of youth with disabilities. OBJECTIVES In order to achieve these aims, our specific objectives are to... 1. Complete a methodologically innovative comprehensive situational analysis, participatory evaluation, mapping, and micro-narrative network survey to identify the current situation of access and participation to skills development, school transition, vocational training, and meaningful work for youth with disabilities in Bhutan. 2. Provide a means for youth with disabilities, families, communities, and employers in Bhutan to voice their experiences related to SCICS. 3. Identify and target the factors within the interconnected relationship of policy, economy, and social institutions in Bhutan that support access to training and meaningful employment for youth with disabilities. 4. Localise and implement an employment assessment toolkit to provide an evaluative framework for the following interventions: a) Offer a series of self-employment, entrepreneurial, vocational skills, and inclusive employment workshops for youth with disabilities, facilitators/coordinators, and employers in Bhutan. b) Pilot the creation of the professional roles of Inclusive Employment Coordinator, Inclusive Entrepreneurship Coordinator, and School Transition Coordinator as new positions in Bhutan, with evaluation on sustainability and scalability. c) Introduce a pilot microfinance scheme specifically for youth with disabilities in Bhutan. 5. Evaluate which current and introduced interventions to support employment for youth with disabilities in Bhutan are culturally appropriate and relevant; can be implemented with high fidelity and successfully sustained, scaled, and most cost-effective for the greatest social and economic impact; and which interventions can be generalized for use in other low and middle-income countries. 6. Develop resources and guidance to support the development and high-fidelity implementation of similar access and participation to SCICS for youth with disabilities in low and middle-income countries.
TREATS-AF:Educational intervention vs usual care on anticoagulation therapy control based on a SAMe-TT2R2 score-guided strategyUK - Department for Business, Energy and Industrial Strategy
1. To conduct a prospective individually-randomised-controlled trial (RCT) in warfarin-naïve Thai AF patients to evaluate the use of a clinical prediction score (modified SAMe-TT2R2 score using non-race factors) to stratify treatment modalities by likely patient response to anticoagulation with warfarin (the most common oral anticoagulant used in Thailand), as measured by the time in therapeutic range (TTR, primary outcome) compared with usual care. In the intervention arm, warfarin-naïve AF patients likely to respond (SAMe-TT2R2 scores 0-2) will be assigned warfarin, whilst poorer responders (SAMe-TT2R2 >2) will be given an educational-behavioural intervention (based on our TREAT trial; PMID:24040156) as an adjunct to their regular international normalized ratio (INR, a measure of the level of anticoagulation) monitoring to improve their TTR on warfarin. 2. To assess the intervention cost-effectiveness. 3. To perform cross-cultural adaptation of the TREAT intervention and translation, validation of the translated patient knowledge questionnaire, and subsequent analysis. 4. To perform a qualitative sub-study to investigate patient satisfaction and acceptance of the TREAT intervention. This would also facilitate research capacity building and development of novel patient-centred tools (e.g. Thai-version of TREAT educational intervention, Thai-language questionnaires, etc.).
Energy Solidarity in Latin America: generating inclusive knowledge and governance to address energy vulnerability and energy systems resilienceUK - Department for Business, Energy and Industrial Strategy
This research has four key objectives, all underpinned by a commitment to co-creating knowledge and solutions to mitigate energy vulnerability (EV), improve energy systems resilience and foster energy solidarity in Cuba, Colombia and Mexico, to promote social welfare, and sustainable development: Speaking to priority areas 1, 3 and 4 of the call (i.e. 'Energy technology interactions...' and 'Effective governance and political economy...'), the first and principal objective of this project (ESLatinA) is to radically transform the extent, depth, and focus of EV knowledge within Latin America. Co-producing holistic and inclusive knowledge, and mechanisms for its generation, is the foundation needed for the recognition of disadvantaged groups, evidence-based policies that foster energy solidarity, and governance that produce just processes and outcomes in energy chains. For this, evidence will be generated in three ways: through analysis of existing secondary data on energy systems, and household energy use; by collecting new inclusive household survey data on a nationally representative-level; and via in-depth community-level participatory workshops. We will increase understanding and self-recognition around energy technologies, services and their use, as well as the differentiated impacts of EV on wellbeing and development opportunities. A second supporting objective is to build capacities at multiple scales within academia, communities, and policy institutions, in order to enhance individual and institutional transformations that reduce inequalities. Formal tools to achieve this will include bespoke Massive Open Online Courses, new university curricula, and capacity-building and training workshops with government officials and communities around understanding and implementing ESLatinA's outputs. Capacity-building and knowledge dissemination will also occur via partnership building and outreach activities, designed to foster solidarity among social actors in the fight against EV. This will include a new pan-Latin American network on energy poverty, community-level exhibits, and the establishment of regional and national-level monitoring observatories. All of the above is intended to build relationships and policy influence among relevant stakeholders (policymakers, community organisations, households, NGOs, researchers, and the private sector), facilitating knowledge exchange, and creating mechanisms for long-term impact. Our third objective is to activate new mechanisms for improving the resilience of energy systems (priority area three). This will be achieved by bringing prevailing energy systems resilience frameworks into conversation with EV via: in-depth technical reviews, national energy system vulnerability mapping and community-level assessments, to advance the state-of-the-art by exploring infrastructural and economic factors while emphasising social dimensions. The work will culminate in new data tools to support decision-makers at both national and local levels in understanding and managing risks associated with energy markets, and infrastructural and social vulnerabilities to phenomena such as hurricanes, migration, and supply shocks. Our fourth and final objective, also addressing priority area four, is to co-create bespoke cutting-edge action plans to address EV. Deriving from our international and national reviews on legal norms for rights to energy and consumer protection, each country will propose innovative legal and regulatory frameworks to bring about sustainable forms of energy access. Building from this benchmarking work, and integrating the knowledge generated across ESLatinA, we will develop bespoke socio-technical EV national and community-level action plans, which address the identified technological and social gaps, and find people-centered energy solutions, focused on building governance and solidarity into ongoing and future investments in sustainable and renewable forms of energy.
Concentrations of fine particulate matter in the atmosphere of Beijing are currently falling year-by-year but annual averages remain stubbornly high in international terms, and haze events caused by elevated PM2.5 are still a regular feature of air quality. A breakdown of the PM2.5 into its major components indicates that all major classes of PM2.5 (e.g. sulphates, nitrates, primary particles etc), other than secondary organic aerosol, are declining in concentration. On the contrary, concentrations of secondary organic aerosol are changing little and if effective mitigation measures are to be developed, better knowledge of the specific precursors of secondary organic particles is urgently needed. This project is concerned with generating such information. The established approach to estimating the contributions of precursors to secondary organic aerosol mass concentrations is by identification of reaction products specific to a particular precursor and using chamber experiments to estimate their relationship to the mass of secondary organic aerosol arising from that precursor. Through measurements of such tracer compounds in the atmosphere, it is then possible to predict the contribution to particle mass. Currently such tracers are available for only four precursor compounds and account for only about 50% of secondary organic aerosol. The objectives of this study are: (a) To conduct studies in the chamber at the Institute of Chemistry of the China Academy of Sciences in which the more abundant high molecular weight organic compounds are subjected to oxidation and the resultant aerosol is sampled. (b) To use advanced analytical techniques not previously deployed in China to identify reaction products as candidate tracers for the secondary organic aerosol produced. (c) To analyse particulate matter from the atmosphere of Beijing in order to quantify the concentrations of the candidate tracer compounds. (d) To analyse primary particles from common combustion sources in order to evaluate possible interferences in the interpretation of tracer data. (e) To use the data collected to provide quantitative source attribution of secondary organic aerosol to the precursors responsible for its formation.