Search Results for: "Liverpool School of Tropical Medicine"
1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMICs. 2) Create an environment where world-class global health research, focused on the needs of LMICs can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMICs. 4) Focus on priority areas which will have the greatest impact on health in LMICs in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice. 8) Retain a level of responsive research capacity to address emerging global health research requirements (Units only).
This programme in the Ross Fund Portfolio (which focusses on neglected tropical diseases, diseases of emerging resistance and diseases of epidemic potential) aims to build the evidence based on effective interventions and delivery mechanisms to tackle infectious diseases in low and middle income countries. The research programmes will take an integrated and multi-disciplinary approach to help DFID and the development community better understand what works most effectively to tackle infectious diseases, building upon the existing evidence base. The research addresses a number of core themes, including delivery through health systems, value for money of interventions, vulnerable groups, gender and building evidence on interventions in a range of contexts including (but not limited to) fragile and conflict affected states.
To avert 4000 maternal deaths and 5500 neonatal deaths through nationwide life saving skills training for health professionals, and integrated health system strengthening in selected counties, 2013-2023
1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMIC. 2) Create an environment where world-class global health research, focused on the needs of LMIC can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMIC. 4) Focus on priority areas which will have the greatest impact on health in LMIC in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice.
1. Deliver research for the primary benefit to the health and welfare of the poorest individuals living in LMICs, typically through research for the prevention of ill health and optimal disease management, in three research areas: (1) Epilepsy (2) Infection-related cancers (3) Severe stigmatising skin diseases. 2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers in the UK and LMICs. 3. Promote interdisciplinary approaches to working (including, but not limited to: clinical, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered.
To improve outcomes for people affected by humanitarian crises by identifying, nurturing and sharing more effective and scalable solutions.
This investment will contribute towards the ultimate goal of achieving the World Health Organisation 2020 Neglected Tropical Disease (NTD) control and elimination targets through the conduct of implementation research alongside the delivery of Integrated NTD Control Programmes on the ground. The research will inform the on-going and future design of cost-effective, sustainable NTD control programmes and their integration within the wider health system at scale.
GCRF: CEPHaS - Strengthening Capacity in Environmental Physics, Hydrology and Statistics for Conservation Agriculture Research.UK - Department for Business, Energy and Industrial Strategy
The aim of this proposal is to undertake learning-centred demonstration trials at established agricultural experiments in Zambia, Zimbabwe and Malawi so as to build capacity for cross-disciplinary research in soil physics, shallow geophysics, hydrogeology and environmental statistics. This will enable partner countries to evaluate the impacts of conservation agriculture practices (and, subsequently, a broader range of agronomic interventions) on the resilience of food production and water security under climate change. Such improved research capacity will empower the African research organizations in our network to deliver understanding of how conservation agriculture, and other similar agronomic practices, can improve the sustainability of smallholder production in central Africa, particularly in the face of increasingly frequent El Niño seasons, and so improve the food security and economic status of rural households. At the same time they will be able to evaluate impacts on these practices on the quality and quantity of groundwater resources. This proposal is therefore directly aligned with the UK AID strategic objective of Strengthening Resilience, and UN Sustainable Development Goals 1 (Poverty), 2 (Hunger), 3 (health and wellbeing) and 6 (clean water). To achieve this aim we have the following objectives i. To build research capacity in our partner institutions in Africa through a combination of formal training and collaborative field and laboratory work in which staff at a range of levels (new graduates to post-doctoral research fellows) develop skills in modern methods in soil physics, shallow geophysics, geohydrology and environmental statistics. ii. To engage collaboratively in project planning, including interactions with a parter NGO who will engage critically with us in the identification of research priorities and, ultimately, the evaluation of results. This partner NGO, the Kasisi Agricultural Training Centre in Zambia, has research experience in both the natural sciences and socio-economic disciplines, and a training and extension role that reaches more than 10,000 small-scale producers. iii. To leave a legacy in terms of training resources and experience, captured in interactive Wiki-style manuals, to complement the legacy in terms of equipment (laboratory and field) and skills. iv. To engage in a formal research capacity strengthening exercise with a collaborative identification of research capacity objectives, an identification of components of research infrastructure and systems needed to achieve those objectives, a baseline assessment of research capacity, collaborative identification of an action plan to achieve the objectives, and regular monitoring and appraisal of progress. This exercise will be undertaken by local staff at each institution under the direction of researchers from the Liverpool School of Tropical Medicine Capacity Research Unit.
To achieve sustained acceleration in the attainment of global TB goals in sub-Saharan Africa by securing changes in policy and practice toward value-for-money, gender sensitive and pro-poor TB interventions. The targeting of vulnerable and marginalised populations, particularly in densely populated urban areas, to generate evidence that will support introduction and scale-up of existing and new TB-related products. To reach, in particular, the ‘missing men’ (including youth) who are hard to reach for TB detection, prevention and treatment, due to a variety of cultural, socio-economic and public health policy factors, and who are disproportionately affected by the disease. To optimise the effective and rapid delivery of existing TB and HIV interventions for men and maximise the impact of interventions and investments within the health systems of low- and lower-middle income African countries as well as provide much-needed evidence to support future access strategies for TB products.
To improve access and utilisation by the poor, vulnerable and marginalised people living in fragile and shock prone settings (FASP) to effective and equitable healthcare, leading to greater financial protection and better health. The programme will deliver research evidence on how to develop resilience capacities to ensure responsive, effective, inclusive, gender-equitable and sustainable health systems in FASP; and disseminate findings, exert influence to help ensure evidence based policy and practice.
Our overarching objective is: To catalyse a step-change globally, nationally and locally in approaches to improving state-citizen accountability and promoting equity in the well-being and health of marginalised people living in poverty in informal urban settlements. We will achieve this through iterative participatory action research cycles of reflection, planning, action and adaptation in four study countries: Bangladesh, India, Kenya and Sierra Leone. These were chosen because they represent variation in types of informal settlement, and wider geographic, socio-cultural, political and economic contexts, as well as providing the opportunity to build on and existing deep and equitable partnerships. We will extend beyond these countries through our responsive fund. There is insufficient global knowledge on the conditions and enablers for the emergence and effectiveness of varied accountability strategies. This is especially the case for contexts with less cohesive social movements, fragmented, pluralistic governance systems and less political space for citizen demands. Our research cycles will work across three, inter-related domains in our Theory of Change: understandings, relationships and action. We will develop new understandings of the linkages between informal urban governance, health and well-being that illuminate underlying power relations and how these shape intersecting inequities and vulnerabilities. Central to this approach is working with urban informal residents to bring a bottom-up analysis of their priorities, diagnose exclusionary and anti-accountability forces, and identify strategies to effectively negotiate with governance actors for change. We will work in partnership with residents to build the necessary relationships and alliances, through convening fora incorporating diverse formal and informal governance actors across sectors and interests. These will jointly reflect on our new insights and data, develop and test action to improve accountability strategies for equity in the social determinants of health and service provision. Our specific objectives are therefore: 1. To work with marginalised people living in poverty in informal urban settlements in study sites, to analyse their priorities and create strategic alliances for collective action to demand improved accountability and responsiveness of services that promote health and well-being. 2. To convene fora that build relationships in study sites and strengthen coalitions between residents of informal urban settlements, formal and informal governance actors and service providers, in order to set priorities, and co-develop and test actions for improved accountability, service provision and system responsiveness for equity in well-being and health. 3. To enhance understanding of effective accountability strategies for equity in well-being and health, identify their contextual enablers and contribute comparative learning that is applicable across informal urban contexts. 4. To develop the evidence base on processes that shape well-being and health outcomes among marginalised people living in informal urban settlements, with respect to gendered social relationships, well-being and health vulnerabilities, resilience, and power relations inherent in governance arrangements that drive intersecting inequities. 5. To develop improved tools, approaches and methods, drawing on interdisciplinary dialogue, to reflect residents' own understandings of their lived realities, to inform engagement of governance actors and multi-sectoral service providers and catalyse impact in policy and programming. 6. To re-frame and actively communicate new conceptual frameworks for accountability for equitable well-being and health in informal urban spaces, and to utilise these to inform global discourse and policy. 7. To develop and sustain an interdisciplinary and equitable partnership and capacities that will have continued impact beyond Hub funding.
1. Develop evidence-based strategies for the control of vector borne disease in Africa 2. Maximise opportunities for integrated vector management by strengthening linkages between disease-specific programmes 3. Strengthen the resilience of African nations to respond to outbreaks of vector borne disease 4. Build stronger links between the supply and demand for evidence at national level 5. Increase the leadership role of African scientists in global policy making on vector borne disease. 6. Develop supportive professional development paths and attract new talent to careers in control of vector borne disease.
Sightsavers’ research function focuses on funding research projects across all themes and technical expertise to research and evidence generation
Accelerating the Sustainable Control and Elimination of Neglected Tropical Diseases (ASCEND - Lot 2) is a high profile, DFID-funded, multi-partner programme, which will make a significant contribution to the control and eliminatuion of the 5 PC NTDs, health systems strengthening, and cross-sector collaboration (particularly WASH and education) across 13 countries in Western and Central Africa. ASCEND - Lot 2 is a single integrated programme across NTDs and the health system, with the following minimum results across the region: 1) provide surgeries to prevent 52,000 cases of blindness due to trachoma 2) 450 million MDA treatments and 3) reduction of morbidity and disability in 26,000 people with lymphatic filariasis.
To support the generation of research and evaluation evidence to improve current understanding of the impact of DFID-funded health research. It will enable better analysis and learning from research data. This will allow DFID, and other research funders, to make better resource allocation decisions and more effectively demonstrate and communicate the contribution of health research to achieving international development objectives.
Accelerating the Sustainable Control and Elimination of Neglected Tropical Diseases (ASCEND - Lot 2) is a high profile, DFID-funded, multi-partner programme, which will make a significant contribution to the control and eliminatuion of the 5 PC NTDs, health systems strengthening, and cross-sector collaboration (particularly WASH and education) across 13 countries in Western and Central Africa. This project code is for central fees and expenses regarding Liverpool School of Tropical Medicine.
1. To collect data that will enable the development of a model of drivers of extended spectrum beta-lactamse producing ESBL E. coli and ESBL Klebsiella pneumoniae transmission in Uganda and Malawi 2. To use the model to predict the critical points at which efforts to interrupt antimicrobial resistant pathogen transmission to humans are likely to have the greatest impact 3. To develop intervention strategies in collaboration with key stakeholders that are likely to be affordable and feasible for future evaluation
Menstrual cups and unconditional cash transfer to reduce sexual and reproductive harm and school drop-out in adolescent schoolgirls in western KenyaUK - Department for Business, Energy and Industrial Strategy
Grand Aim: Inform evidence-based policy to develop intervention programmes which improve adolescent girls' health, school equity and life-chances. 1. Primary Trial Objective: To determine if menstrual cups or unconditional cash transfer alone, or in combination, provided to secondary schoolgirls, will significantly reduce a composite of deleterious outcomes (HIV, HSV-2 infection, or school drop-out) which compromise girls' ability to stay in school and lead healthy lives. 2. Secondary objectives - Research: 2.1. To measure the protective efficacy of menstrual cups, cash transfer, alone and in combination, on a composite outcome of HIV, HSV-2, and school drop-out over a 2-year intervention period. 2.2. To measure the age-specific HIV, HSV-2 incidence in secondary schoolgirls and risk factors for incident HIV and HSV-2 infections. 2.3. To determine the risk, risk factors and reasons for drop-out of secondary school, examining the influence of social, epidemiological, and/or health characteristics. 2.4. To determine the cost of menstrual cup and unconditional cash transfer programmes for schoolgirls, and the cost savings of outcomes averted, for individual and combined interventions, and calculate the estimated societal impact. 2.5. To determine the safety of menstrual cups use, including risk of cup contamination over time, serious adverse events, and identify factors that increase or modify this risk. 2.6. To determine factors affecting how adolescent girls spend cash transfer money, and what training is required to support their decision making. 2.7. To determine any adverse outcomes associated with cash transfer provision, and evaluate ways to minimize this risk. 2.8. To determine the impact of the interventions on girls' sexual behaviours, including age of sexual début, transactional sex, number of partners, age discordance of partners, and use of contraception. 2.9. To develop local research capacity to conduct intervention studies among adolescent girls, and school-based studies, including epidemiological, clinical, social science and behaviour, and laboratory skills. 2.10. To provide trial results to the research consortia on menstrual management, as an evidence based platform to support further research. 3. Secondary Objectives - Translation of research into best practice: 3.1. To examine programme implementation implications for providing interventions in schools. 3.2. To work with beneficiaries and stakeholders to develop implementation packages, to inform and guide programme scale up. 3.3. To utilise research data to inform and support Kenya Ministry of Health and Education policy and programme activities. 3.4. To translate research findings into policy and practice, in collaboration with government officials, researchers, programme specialists, NGOs, aid agencies, donors, and international organizations. 3.5. To share research with DfID Kenya and partners to inform allied studies aiming to support school retention among adolescent girls. 3.6. To contribute research findings to the development of holistic packages to improve the quality of life of schoolgirls. 3.7. To contribute research tools and methods used towards monitoring and evaluation of school health intervention programmes, such as WASH in schools. 3.8. To use the research findings to raise the profile of adolescent girls unmet needs, at local, national and international level, to promote funding for implementation of programmes. 3.9. To utilize research methods and findings to support the newly founded research consortia on menstrual hygiene management for schoolgirls, to provide a platform for advocacy and systematic development of global policy and implementation.
Sightsavers’ function focussing on detailed oversight and management support for significant grant funded projects, ensuring that they are set up, implemented and reported on effectively and with appropriate support from other organisational functions